Histone Deacetylase Inhibition as a Treatment of TRAIL-Resistant Cancers

Neuzil, J., Andera, L. and Gabrielli, B. (2005). Histone Deacetylase Inhibition as a Treatment of TRAIL-Resistant Cancers. In Mels Sluyser (Ed.), Application of Apoptosis to Cancer Treatment (pp. 271-291) Netherlands: Springer.


Author Neuzil, J.
Andera, L.
Gabrielli, B.
Title of chapter Histone Deacetylase Inhibition as a Treatment of TRAIL-Resistant Cancers
Title of book Application of Apoptosis to Cancer Treatment
Place of Publication Netherlands
Publisher Springer
Publication Year 2005
Sub-type Research book chapter (original research)
ISBN 978-1-4020-3303-2
978-1-4020-3302-5
Editor Mels Sluyser
Chapter number 12
Start page 271
End page 291
Total pages 21
Total chapters 1
Language eng
Subjects 060103 Cell Development, Proliferation and Death
111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy)
Abstract/Summary Histone deacetylas inhibitors (HDIs) are a novel prospective group of potential anti-cancer agents, some of them being tested in a clinical setting. The major mode of action of these compounds is inhibition of the cell cycle transition and, consequently, differential regulation of a number of genes necessary for cell proliferation, while favouring expression of genes rather associated with anti-proliferative pathways and with cell death signalling. This implies a possible role of HDIs in adjuvant treatment of tumours resistant to other agents, operating via a different molecular mechanism. The TNF-related apoptosis-inducing ligant (TRAIL) is a promising immunological inducer of apoptosis efficient against a variety of tumours with a remarkably selective mode of action. However, some malignancies are resistant to TRAIL treatment. In this paper, we review our current knowledge on HDI-mediated sensitisation of TRAIL-non-responsive tumours to this apoptogen and suggest a future clinical potential of HDIs and TRAIL in cancer management.
Keyword Apoptosis
cell cycle arrest
death receptor
histone deacetylase inhibitor
Q-Index Code B1

 
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Created: Tue, 13 Jan 2009, 16:50:15 EST by Gina Velli on behalf of UQ Diamantina Institute