Suppressing effects of bisphenol A on the secretory function of ovine anterior pituitary cells

Katoh, K, Matsuda, A, Ishigami, A, Yonekura, S, Ishiwata, H, Chen, C and Obara, Y (2004) Suppressing effects of bisphenol A on the secretory function of ovine anterior pituitary cells. Cell Biology International, 28 6: 463-469. doi:10.1016/j.cellbi.2004.03.016


Author Katoh, K
Matsuda, A
Ishigami, A
Yonekura, S
Ishiwata, H
Chen, C
Obara, Y
Title Suppressing effects of bisphenol A on the secretory function of ovine anterior pituitary cells
Journal name Cell Biology International   Check publisher's open access policy
ISSN 1065-6995
Publication date 2004-06
Year available 2004
Sub-type Article (original research)
DOI 10.1016/j.cellbi.2004.03.016
Volume 28
Issue 6
Start page 463
End page 469
Total pages 7
Place of publication London
Publisher Academic Press
Language eng
Subject 110306 Endocrinology
110201 Cardiology (incl. Cardiovascular Diseases)
111201 Cancer Cell Biology
Abstract We investigated the action of bisphenol A (BPA) on cellular GH release and content, cell number, GHmRNA expression, and concentrations of cellular cyclic AMP ([cAMP]c) and calcium ion ([Ca2+]c) in primary cultured ovine anterior pituitary cells. The following results were found: (1) BPA as well as nonylphenol (NP) at 10−6 to 10−3 M significantly and concentration-dependently suppressed basal and GHRH-stimulated GH release, and the cellular GH content, (2) BPA suppressed the cell number in a time- and concentration-dependent manner, (3) 10−4 M BPA suppressed GHmRNA expression to 68% of control (BPA-free), and abolished GHRH (10−8 M)-induced increases in [cAMP]c and [Ca2+]c. From these findings we conclude that BPA possesses a suppressing action on GH synthesis and release, and this suppressing action is probably related to impairment of cellular signal transduction systems in ovine anterior pituitary cells.
Keyword Bisphenol A
cellular GH
Q-Index Code C1
Additional Notes Official journal of International Federation for Cell Biology

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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