Efficacy of DNA and Fowlpox Virus Priming/Boosting Vaccines for Simian/Human Immunodeficiency Virus

Dale, C. J., De Rose, R., Stratov, I., Chea, S., Montefiori, D. C., Thomson, S., Ramshaw, A., Coupar, B. E. H., Boyle, D. B., Law, M. and Kent, S. J. (2004) Efficacy of DNA and Fowlpox Virus Priming/Boosting Vaccines for Simian/Human Immunodeficiency Virus. Journal of Virology, 78 24: 13819-13828. doi:10.1128/JVI.78.24.13819-13828.2004

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Author Dale, C. J.
De Rose, R.
Stratov, I.
Chea, S.
Montefiori, D. C.
Thomson, S.
Ramshaw, A.
Coupar, B. E. H.
Boyle, D. B.
Law, M.
Kent, S. J.
Title Efficacy of DNA and Fowlpox Virus Priming/Boosting Vaccines for Simian/Human Immunodeficiency Virus
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
1098-5514
Publication date 2004-12-01
Year available 2004
Sub-type Article (original research)
DOI 10.1128/JVI.78.24.13819-13828.2004
Open Access Status File (Publisher version)
Volume 78
Issue 24
Start page 13819
End page 13828
Total pages 10
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2004
Language eng
Subject 110704 Cellular Immunology
Abstract urther advances are required in understanding protection from AIDS by T-cell immunity. We analyzed a set of multigenic simian/human immunodeficiency virus (SHIV) DNA and fowlpox virus priming and boosting vaccines for immunogenicity and protective efficacy in outbred pigtail macaques. The number of vaccinations required, the effect of DNA vaccination alone, and the effect of cytokine (gamma interferon) coexpression by the fowlpox virus boost was also studied. A coordinated induction of high levels of broadly reactive CD4 and CD8 T-cell immune responses was induced by sequential DNA and fowlpox virus vaccination. The immunogenicity of regimens utilizing fowlpox virus coexpressing gamma interferon, a single DNA priming vaccination, or DNA vaccines alone was inferior. Significant control of a virulent SHIV challenge was observed despite a loss of SHIV-specific proliferating T cells. The outcome of challenge with virulent SHIVmn229 correlated with vaccine immunogenicity except that DNA vaccination alone primed for protection almost as effectively as the DNA/fowlpox virus regimen despite negligible immunogenicity by standard assays. These studies suggest that priming of immunity with DNA and fowlpox virus vaccines could delay AIDS in humans.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Clinical Medical Virology Centre Publications
 
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