Effects Of Molybdenum, Silicon And Nickel On α1-Adrenoceptor-Induced Constriction Of Rat Isolated Aorta

Liu, Dong Ling, Yan, Ming, Chua, Yeow Leng, Chen, Chen and Lim, Yean Leng (2002) Effects Of Molybdenum, Silicon And Nickel On α1-Adrenoceptor-Induced Constriction Of Rat Isolated Aorta. Clinical and Experimental Pharmacology and Physiology, 29 5-6: 395-398. doi:10.1046/j.1440-1681.2002.03674.x


Author Liu, Dong Ling
Yan, Ming
Chua, Yeow Leng
Chen, Chen
Lim, Yean Leng
Title Effects Of Molybdenum, Silicon And Nickel On α1-Adrenoceptor-Induced Constriction Of Rat Isolated Aorta
Formatted title
Effects Of Molybdenum, Silicon And Nickel On α1-Adrenoceptor-Induced Constriction Of Rat Isolated Aorta
Journal name Clinical and Experimental Pharmacology and Physiology   Check publisher's open access policy
ISSN 0305-1870
1440-1681
Publication date 2002
Sub-type Article (original research)
DOI 10.1046/j.1440-1681.2002.03674.x
Volume 29
Issue 5-6
Start page 395
End page 398
Total pages 4
Place of publication Oxford
Publisher Blackwell Scientific Publications
Language eng
Subject 270000 Biological Sciences
Abstract 1. To determine the effects of trace elements on α1-adrenoceptor-mediated vasoconstriction, we studied the effects of molybdenum (Mo), silicon (Si) and nickel (Ni) on vasoconstrictor response to an α1-adrenoceptor agonist in rat aorta. 2. Cumulative concentration–contraction curves were obtained for phenylephrine (1 nmol/L–10 μmol/L) in the absence and presence of Mo, Si and Ni (0.3, 1 and 3 μmol/L) in rat aorta rings. Increasing the concentration of Mo and Si from 0.3 to 3 μmol/L shifted the cumulative concentration–contraction curve to the right, but did not reduce the maximal contractile response to phenylephrine. In contrast, Ni at 1 and 3 μmol/L shifted the cumulative concentration–contraction curve to the right and, at 3 μmol/L, reduced the maximum contractile response to phenylephrine. 3. We conclude that micromolar concentrations of Mo, Si and Ni affected α1-adrenoceptor-induced vasoconstriction and that Ni significantly inhibited the maximal contractile response to phenylephrine in rat isolated aorta.
Formatted abstract
1. To determine the effects of trace elements on α1-adrenoceptor-mediated vasoconstriction, we studied the effects of molybdenum (Mo), silicon (Si) and nickel (Ni) on vasoconstrictor response to an α1-adrenoceptor agonist in rat aorta.

2. Cumulative concentration–contraction curves were obtained for phenylephrine (1 nmol/L–10 μmol/L) in the absence and presence of Mo, Si and Ni (0.3, 1 and 3 μmol/L) in rat aorta rings. Increasing the concentration of Mo and Si from 0.3 to 3 μmol/L shifted the cumulative concentration–contraction curve to the right, but did not reduce the maximal contractile response to phenylephrine. In contrast, Ni at 1 and 3 μmol/L shifted the cumulative concentration–contraction curve to the right and, at 3 μmol/L, reduced the maximum contractile response to phenylephrine.

3. We conclude that micromolar concentrations of Mo, Si and Ni affected α1-adrenoceptor-induced vasoconstriction and that Ni significantly inhibited the maximal contractile response to phenylephrine in rat isolated aorta.
Keyword α 1-adrenoceptor
Molybdenum
Nickel
silicon
rat aorta
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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