Tyrosine kinase inhibitors suppress α1-adrenoceptor mediated contraction in human radial, internal mammary arteries and saphenous vein

Yan, Ming, Liua, Dong Ling, Chuaa, Yeow Leng, Chen, Chen and Lim, Yean Leng (2002) Tyrosine kinase inhibitors suppress α1-adrenoceptor mediated contraction in human radial, internal mammary arteries and saphenous vein. Neuroscience letters, 333 3: 171-174. doi:10.1016/S0304-3940(02)00877-7


Author Yan, Ming
Liua, Dong Ling
Chuaa, Yeow Leng
Chen, Chen
Lim, Yean Leng
Title Tyrosine kinase inhibitors suppress α1-adrenoceptor mediated contraction in human radial, internal mammary arteries and saphenous vein
Journal name Neuroscience letters   Check publisher's open access policy
ISSN 0304-3940
Publication date 2002-11-29
Sub-type Article (original research)
DOI 10.1016/S0304-3940(02)00877-7
Volume 333
Issue 3
Start page 171
End page 174
Total pages 4
Place of publication Amsterdam
Publisher Elsevier
Language eng
Subject 270000 Biological Sciences
Abstract The aim of this study is to determine whether the tyrosine kinase plays a role in the contractile response of human radial artery (RA), internal mammary artery (IMA) and saphenous vein (SV) to a1-adrenoceptor (AR) stimulation. The tyrosine kinase inhibitors, genistein and tyrphostin, significantly inhibited a1-AR mediated contractile response in a dose-dependent and non-competitive manner. Genistein at 10 mMinhibited 39%, 54% and 72% of PE-induced maximum contraction, and tyrphostin at 50 mM inhibited 41%, 68% and 39% of the contraction in the human RA, IMA and SV respectively. These results suggest that tyrosine kinases participate in regulation of signal transduction that is associated with a1-AR mediated contractile response in human blood vessels.
Keyword Tyrosine Kinase
Human blood vessels
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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