Histamine promotes excitability in bovine adrenal chromaffin cells by inhibiting an M-current

Wallace, Damian J, Chen, Chen and Marley, Philip D (2002) Histamine promotes excitability in bovine adrenal chromaffin cells by inhibiting an M-current. The journal of physiology, 540 3: 921-939. doi:10.1113/jphysiol.2001.013370

Author Wallace, Damian J
Chen, Chen
Marley, Philip D
Title Histamine promotes excitability in bovine adrenal chromaffin cells by inhibiting an M-current
Journal name The journal of physiology   Check publisher's open access policy
ISSN 0022-3751
Publication date 2002
Year available 2002
Sub-type Article (original research)
DOI 10.1113/jphysiol.2001.013370
Volume 540
Issue 3
Start page 921
End page 939
Total pages 19
Place of publication Oxford
Publisher Blackwell for the Physiological Society
Collection year 2002
Language eng
Subject 110306 Endocrinology
110201 Cardiology (incl. Cardiovascular Diseases)
111201 Cancer Cell Biology
Abstract The current study has investigated the electrophysiological responses evoked by histamine in bovine adrenal chromaffin cells using perforated-patch techniques. Histamine caused a transient hyperpolarization followed by a sustained depolarization of 7.2 ±1.4 mV associated with an increase in spontaneous action potential frequency. The hyperpolarization was abolished after depleting intracellular Ca2+ stores with thapsigargin (100 nM), and was reduced by 40 % with apamin (100 nM). Membrane resistance increased by about 60 % during the histamine-induced depolarization suggesting inhibition of a K+ channel. An inward current relaxation, typical of an Mcurrent, was observed in response to negative voltage steps from a holding potential of _30 mV. This current reversed at _81.6 ±1.8 mV and was abolished by the M-channel inhibitor linopirdine (100 mM). During application of histamine, the amplitude of M-currents recorded at a time corresponding with the sustained depolarization was reduced by 40 %. No inward current rectification was observed in the range _150 to _70 mV, and glibenclamide (10 mM) had no effect on either resting membrane potential or the response to histamine. The results show that an M-current is present in bovine chromaffin cells and that this current is inhibited during sustained application of histamine, resulting in membrane depolarization and increased discharge of action potentials. These results demonstrate for the first time a possible mechanism coupling histamine receptors to activation of voltage-operated Ca2+ channels in these cells.
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