Combination aerosol therapy to treat Burkholderia cepacia complex

Middleton, P. G., Kidd, T. J. and Williams, B. (2005) Combination aerosol therapy to treat Burkholderia cepacia complex. The European Respiratory Journal, 26 2: 305-308. doi:10.1183/09031936.05.00119504

Author Middleton, P. G.
Kidd, T. J.
Williams, B.
Title Combination aerosol therapy to treat Burkholderia cepacia complex
Journal name The European Respiratory Journal   Check publisher's open access policy
ISSN 0903-1936
Publication date 2005-05-03
Year available 2005
Sub-type Article (original research)
DOI 10.1183/09031936.05.00119504
Volume 26
Issue 2
Start page 305
End page 308
Total pages 6
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Language eng
Subject 111502 Clinical Pharmacology and Therapeutics
Formatted abstract
Burkholderia cepacia infection in cystic fibrosis (CF) patients is associated with significant morbidity and mortality, yet no definitive treatment is currently available. This report describes a new approach to treat B. cepacia infection in CF patients, using a combination of amiloride and tobramycin aerosols.

Four adults with the typical clinical syndrome of CF were recruited after repeated positive sputum cultures for B. cepacia. Aerosols of amiloride and tobramycin were given three times daily for 1–6 months, and repeated sputum cultures were collected to assess efficacy.

Three of the four patients treated with the combined therapy eradicated B. cepacia from their sputum cultures for at least 2 yrs, and there were no adverse events.

This novel combination may provide a new therapeutic option for Burkholderia cepacia infections. Furthermore, the strategy of combining antibiotics with ion transport agents may have ramifications for the treatment of other multi-resistant organisms.
Keyword Aerosol
Burkholderia cepacia complex
cystic fibrosis
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Institutional Status Non-UQ

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Sub-type: Article (original research)
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