Safety and immunogenicity of a combined DTPa–IPV vaccine administered as a booster from 4 years of age: A review

Jacquet, J. M., Bégué, P., Grimprel, E., Reinert, P., Sandbu, S., Silfverdal, S. A., Faldella, G., Nolan, T., Lambert, S., Richmond, P., Marshall, I., Roberton, D. and Schuerman, L. (2006) Safety and immunogenicity of a combined DTPa–IPV vaccine administered as a booster from 4 years of age: A review. Vaccine, 24 13: 2440-2448. doi:10.1016/j.vaccine.2005.12.009


Author Jacquet, J. M.
Bégué, P.
Grimprel, E.
Reinert, P.
Sandbu, S.
Silfverdal, S. A.
Faldella, G.
Nolan, T.
Lambert, S.
Richmond, P.
Marshall, I.
Roberton, D.
Schuerman, L.
Title Safety and immunogenicity of a combined DTPa–IPV vaccine administered as a booster from 4 years of age: A review
Journal name Vaccine   Check publisher's open access policy
ISSN 0264-110X
1873-2518
Publication date 2006-03
Sub-type Article (original research)
DOI 10.1016/j.vaccine.2005.12.009
Volume 24
Issue 13
Start page 2440
End page 2448
Total pages 9
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Subject 111716 Preventive Medicine
111403 Paediatrics
Abstract A combined DTPa–IPV booster vaccine was administered as a 4th or 5th dose after DTPa or DTPw priming. Over 99% vaccines developed antibody levels considered to be protective to diphtheria, tetanus and poliovirus, and >95% mounted a response to acellular pertussis antigens. Rectal temperature >39.5 °C was observed in at most 3.2% of vaccinees. Swelling >50 mm occurred in 24% of DTPa-primed compared to 5.5% of DTPw-primed children. Large swelling involving the entire upper arm (extending to involve the elbow joint) was reported for up to 1.2% of DTPa-primed subjects, which is consistent with literature reports for other DTPa vaccines.
Keyword Immunogenicity
Vaccine-associated adverse events
Acellular pertussis vaccine
Booster vaccination
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Clinical Medical Virology Centre Publications
 
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Created: Fri, 09 Jan 2009, 16:16:28 EST by Sophie Jordan on behalf of Clinical Medical Virology Centre