Estimating Influenza Vaccine Effectiveness in an Outbreak When Anti-viral Medications Were Used as a Control Measure

Guy, Rebecca, Kelly, Heath and Lambert, Stephen (2005) Estimating Influenza Vaccine Effectiveness in an Outbreak When Anti-viral Medications Were Used as a Control Measure. Australian & New Zealand Journal of Public Health, 29 6: 540-543. doi:10.1111/j.1467-842X.2005.tb00247.x


Author Guy, Rebecca
Kelly, Heath
Lambert, Stephen
Title Estimating Influenza Vaccine Effectiveness in an Outbreak When Anti-viral Medications Were Used as a Control Measure
Journal name Australian & New Zealand Journal of Public Health   Check publisher's open access policy
ISSN 1326-0200
Publication date 2005-12
Sub-type Article (original research)
DOI 10.1111/j.1467-842X.2005.tb00247.x
Volume 29
Issue 6
Start page 540
End page 543
Total pages 4
Place of publication Carlton
Publisher Blackwell Publishing
Language eng
Subject 111706 Epidemiology
110804 Medical Virology
Abstract Objectives: To estimate influenza vaccine effectiveness (VE) from an outbreak of influenza A in an aged care facility in which neuraminidase inhibitors were used as part of outbreak control measures. Methods: The outbreak occurred between 25 December 2001 and 21 January 2002. Neuraminidase inhibitors were used to control the outbreak. Residents and staff with respiratory symptoms were tested for influenza using RT-PCR and/or serology. Vaccine effectiveness (VE) was estimated for the prevention of laboratory-confirmed influenza. Results: Nineteen of 42 (45%) residents and four of 29 (14%) staff were laboratoryconfirmed as cases. The outbreak was caused by an influenza A (H3N2) strain, antigenically matched to that season’s vaccine. The VE for preventing laboratoryconfirmed influenza infection was 61% (95% CI 41-73) among residents and 100% (95% CI 63-100) among staff. Conclusions: The VE estimates calculated from this outbreak were consistent with other published results. Outbreaks of influenza in institutions provide a good opportunity to review influenza VE, but use of antiviral medications as control measures may affect interpretation of findings.
Keyword Influenza
Vaccine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Clinical Medical Virology Centre Publications
 
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