Plasma membrane calcium pump isoform 4 (PMCA4) and colon cancer

Chan, K. F., Aung, C. S., Roberts-Thomson, S. J. and Monteith, G. R. (2008). Plasma membrane calcium pump isoform 4 (PMCA4) and colon cancer. In: Abstracts of ComBio 2008. ComBio 2008, Canberra National Convention Centre, (101-101). 21-25 September, 2008.


Author Chan, K. F.
Aung, C. S.
Roberts-Thomson, S. J.
Monteith, G. R.
Title of paper Plasma membrane calcium pump isoform 4 (PMCA4) and colon cancer
Conference name ComBio 2008
Conference location Canberra National Convention Centre
Conference dates 21-25 September, 2008
Proceedings title Abstracts of ComBio 2008
Publication Year 2008
Year available 2008
Sub-type Published abstract
Open Access Status
Start page 101
End page 101
Total pages 1
Language eng
Abstract/Summary Plasma membrane Ca2+-ATPases are responsible for the efflux of calcium ions across the plasma membrane and hence maintaining low levels of resting intracellular free Ca2+. Four genes encode for plasma membrane Ca2+-ATPases (PMCA 1-4). Increases in the expression of the plasma membrane calcium pump isoform 4 (PMCA4) occur in HT-29 colon cancer cell lines after sodium butyrate and post-confluency-induced differentiation, with no similar change in the other isoform expressed in HT-29 cells, PMCA1. Some clinical colon cancer samples are characterized by reduced levels of plasma membrane calcium pump mRNA suggesting that the less differentiated cells have compromised calcium efflux. Studies assessing the effects of PMCA4 overexpression and PMCA4 siRNA in HT-29 cancer cells suggest that the remodeling of calcium efflux in colon cancer cells does not increase sensitivity to apoptotic stimuli but instead may promote pathways important in the invasiveness and proliferation of colon cancer cells, through alterations in cell signaling and gene transcription, in particular that of early response genes
Subjects E3
0601 Biochemistry and Cell Biology
Q-Index Code EX
Q-Index Status Provisional Code

Document type: Conference Paper
Collection: School of Pharmacy Publications
 
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