Analysis of the contributions of herpes simplex virus type 1 membrane proteins to the induction of cell-cell fusion

Davis-Poynter, Nicholas, Bell, Susanne, Minson, Tony and Browne, Helena (1994) Analysis of the contributions of herpes simplex virus type 1 membrane proteins to the induction of cell-cell fusion. Journal of Virology, 68 11: 7586-7590.

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Author Davis-Poynter, Nicholas
Bell, Susanne
Minson, Tony
Browne, Helena
Title Analysis of the contributions of herpes simplex virus type 1 membrane proteins to the induction of cell-cell fusion
Journal name Journal of Virology   Check publisher's open access policy
ISSN 1098-5514
1098-5514
Publication date 1994-11-01
Year available 1994
Sub-type Other
Open Access Status File (Publisher version)
Volume 68
Issue 11
Start page 7586
End page 7590
Total pages 5
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Subject 060506 Virology
0601 Biochemistry and Cell Biology
Abstract The contributions of a set of herpes simplex virus type 1 membrane proteins towards the process of cell-cell fusion were examined with a series of deletion mutants into which a syncytial mutation had been introduced at codon 855 of the glycoprotein B (gB) gene. Analysis of the fusion phenotypes of these recombinant viruses in Vero cells revealed that while gC, gG, US5, and UL43 are dispensable for syncytium formation at both high and low multiplicities of infection, gD, gHgL, gE, gI, and gM were all required for the fusion of cellular membranes. These data confirm that the requirements for virion entry and cell-cell fusion are not identical. gD and gHgL, like gB, are essential for both processes. gG, gI, and gM, on the other hand, are dispensable for virus penetration, yet play a role in cell-to-cell spread by the direct contact route, at least on an SC16 gBANG background.
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Other
Collections: School of Medicine Publications
Clinical Medical Virology Centre Publications
 
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Created: Wed, 07 Jan 2009, 02:06:05 EST by Judy Dingwall on behalf of Clinical Medical Virology Centre