Diffusion indices on magnetic resonance imaging and neuropsychological performance in amnestic mild cognitive impairment

Rose, Stephen E., McMahon, Katie L., Janke, Andrew L., O'Dowd, B, De Zubicaray, Greig I. and Chalk, Jonathan B. (2006) Diffusion indices on magnetic resonance imaging and neuropsychological performance in amnestic mild cognitive impairment. Journal of Neurology, Neurosurgery and Psychiatry, 77 10: 1122-1128. doi:10.1136/jnnp.2005.074336

Author Rose, Stephen E.
McMahon, Katie L.
Janke, Andrew L.
O'Dowd, B
De Zubicaray, Greig I.
Chalk, Jonathan B.
Title Diffusion indices on magnetic resonance imaging and neuropsychological performance in amnestic mild cognitive impairment
Journal name Journal of Neurology, Neurosurgery and Psychiatry   Check publisher's open access policy
ISSN 0022-3050
Publication date 2006-10
Sub-type Article (original research)
DOI 10.1136/jnnp.2005.074336
Volume 77
Issue 10
Start page 1122
End page 1128
Total pages 7
Editor M. N. Rossor
J. O'Flaherty
Place of publication London, U.K
Publisher BMJ Publishing
Language eng
Subject 1109 Neurosciences
Formatted abstract
Background: Magnetic resonance diffusion tensor imaging (DTI) shows promise in the early detection of microstructural pathophysiological changes in the brain.

Objectives: To measure microstructural differences in the brains of participants with amnestic mild cognitive impairment (MCI) compared with an age-matched control group using an optimised DTI technique with fully automated image analysis tools and to investigate the correlation between diffusivity measurements and neuropsychological performance scores across groups.

Methods: 34 participants (17 participants with MCI, 17 healthy elderly adults) underwent magnetic resonance imaging (MRI)-based DTI. To control for the effects of anatomical variation, diffusion images of all participants were registered to standard anatomical space. Significant statistical differences in diffusivity measurements between the two groups were determined on a pixel-by-pixel basis using gaussian random field theory.

Results: Significantly raised mean diffusivity measurements (p<0.001) were observed in the left and right entorhinal cortices (BA28), posterior occipital–parietal cortex (BA18 and BA19), right parietal supramarginal gyrus (BA40) and right frontal precentral gyri (BA4 and BA6) in participants with MCI. With respect to fractional anisotropy, participants with MCI had significantly reduced measurements (p<0.001) in the limbic parahippocampal subgyral white matter, right thalamus and left posterior cingulate. Pearson’s correlation coefficients calculated across all participants showed significant correlations between neuropsychological assessment scores and regional measurements of mean diffusivity and fractional anisotropy.

Conclusions: DTI-based diffusivity measures may offer a sensitive method of detecting subtle microstructural brain changes associated with preclinical Alzheimer’s disease.
Keyword DT-MRI data
Hippocampal volume
Tensor MRI
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 112 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 18 Dec 2008, 12:33:50 EST by Diana Guillemin on behalf of School of Mathematics & Physics