Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms

Wilkinson, Ashley S., Monteith, Gregory R., Shaw, P. Nicholas, Lin, Chun-Nam, Gidley, Michael J. and Roberts-Thomson, Sarah J. (2008) Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. Journal of Agricultural and Food Chemistry, 56 9: 3037-3042. doi:10.1021/jf800046n


Author Wilkinson, Ashley S.
Monteith, Gregory R.
Shaw, P. Nicholas
Lin, Chun-Nam
Gidley, Michael J.
Roberts-Thomson, Sarah J.
Title Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms
Journal name Journal of Agricultural and Food Chemistry   Check publisher's open access policy
ISSN 0021-8561
Publication date 2008
Year available 2008
Sub-type Article (original research)
DOI 10.1021/jf800046n
Volume 56
Issue 9
Start page 3037
End page 3042
Total pages 6
Editor J. N. Seiber
Place of publication Easton, PA. U.S.A.
Publisher American Chemical Society
Collection year 2009
Language eng
Subject 060199 Biochemistry and Cell Biology not elsewhere classified
860105 Nutraceuticals and Functional Foods
0601 Biochemistry and Cell Biology
1111 Nutrition and Dietetics
111199 Nutrition and Dietetics not elsewhere classified
C1
Abstract Mangos are a source of bioactive compounds with potential health-promoting activity. This study evaluated the abilities of the mango components quercetin and mangiferin and the aglycone derivative of mangiferin, norathyriol, to modulate the transactivation of peroxisome proliferator-activated receptor isoforms (PPARs). PPARs are transcription factors important in many human diseases. Through the use of a gene reporter assay it was shown that quercetin inhibited the activation of all three isoforms of PPARs (PPARγ IC50 = 56.3 µM; PPARα IC50 = 59.6 µM; PPARβ IC50 = 76.9 µM) as did norathyriol (PPARγ IC50 = 153.5 µM; PPARα IC50 = 92.8 µM; PPARβ IC50 = 102.4 µM), whereas mangiferin did not inhibit the transactivation of any isoform. These findings suggest that mango components and metabolites may alter transcription and could contribute to positive health benefits via this or similar mechanisms.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Pharmacy Publications
 
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Created: Wed, 10 Dec 2008, 14:22:47 EST by Elizabeth Pyke on behalf of School of Pharmacy