Use of tick antitoxin serum (TAS) and associated drug therapies for the management of Ixodes holocyclus toxicity in dogs

Schull, Daniel (2008). Use of tick antitoxin serum (TAS) and associated drug therapies for the management of Ixodes holocyclus toxicity in dogs PhD Thesis, School of Veterinary Science, The University of Queensland.

       
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n33309260_PHD_abstract.pdf Final Thesis ABSTRACT Lodgement application/pdf 6.08KB 19
n33309260_PHD_totalthesis.pdf Final Thesis Lodgement application/pdf 3.45MB 41
Author Schull, Daniel
Thesis Title Use of tick antitoxin serum (TAS) and associated drug therapies for the management of Ixodes holocyclus toxicity in dogs
School, Centre or Institute School of Veterinary Science
Institution The University of Queensland
Publication date 2008-05
Thesis type PhD Thesis
Supervisor Rick Atwell
Caroline O'Leary
Total pages 242
Total colour pages 12
Total black and white pages 230
Language eng
Subjects 300000 Agricultural, Veterinary and Environmental Sciences
Formatted abstract
The objective of this thesis was to enhance the way tick antitoxin serum (TAS) and associated drug therapies are used in the management of Ixodes holocyclus toxicity in dogs. A review of current literature; a cross-sectional retrospective survey and a series of five prospective randomised placebo-controlled clinical studies were performed. The following results were generated: (1) a synopsis describing how TAS and associated drug therapies are currently used for the management of tick toxicity in dogs by clinicians in practice; (2) the perceptions of clinicians regarding the nature of acute side effects associated with TAS administration in dogs with tick toxicity; (3) clinical characterisation of acute side effects associated with the administration of TAS in healthy conscious dogs when given according to currently accepted techniques; (4) evidence regarding the aetiology of acute side effects associated with the administration of TAS in dogs; (5) clinical characterisation of the cardiovascular effects of ancillary drug therapies including TAS premedicants when given according to current recommendations; (6) the efficacy of recommended premedicants in the prevention of acute side effects associated with the administration of TAS in healthy conscious dogs; and (7) practical recommendations for the use of TAS and associated drug therapies for the management of tick toxicity in dogs. This thesis generates important new information concerning the use of TAS and associated drug therapies for the management of tick toxicity in dogs. Findings from this thesis will improve the way dogs with tick toxicity are managed by veterinary clinicians and have highlighted future research directions in this previously unexplored area.
Additional Notes Colour pages - Page numbers 55, 78, 79, 80, 114, 137, 139, 142, 165, 166, 167, 195

 
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Created: Sat, 25 Oct 2008, 16:10:49 EST by Mr Daniel Schull on behalf of School of Veterinary Science