Derivation of the distensibility coefficient using tissue Doppler as a marker of arterial function

Haluska, B. A., Short, L., Brown, J., Downey, M., Carlier, S. and Marwick, T. H. (2008) Derivation of the distensibility coefficient using tissue Doppler as a marker of arterial function. Clinical Science, 114 6: 441-447. doi:10.1042/CS20070295

Author Haluska, B. A.
Short, L.
Brown, J.
Downey, M.
Carlier, S.
Marwick, T. H.
Title Derivation of the distensibility coefficient using tissue Doppler as a marker of arterial function
Journal name Clinical Science   Check publisher's open access policy
ISSN 0143-5221
Publication date 2008
Sub-type Article (original research)
DOI 10.1042/CS20070295
Volume 114
Issue 6
Start page 441
End page 447
Total pages 7
Editor Dominiczak, A.
Place of publication U,K.
Publisher Portland Press
Collection year 2009
Language eng
Subject C1
321003 Cardiology (incl. Cardiovascular Diseases)
730106 Cardiovascular system and diseases
110201 Cardiology (incl. Cardiovascular Diseases)
11 Medical and Health Sciences
1103 Clinical Sciences
Abstract To date, the main cardiovascular application of TDI (tissue Doppler imaging) has been in myocardial evaluation. In the present study, we investigated the feasibility and reproducibility of assessing arterial elasticity using the DC (distensibility coefficient) measured by TDI, the correlation of this with the DC obtained by other methods and the DC in patients with various degrees of cardiovascular risk. We studied 450 subjects (256 men; age, 51±10 years) with and without risk factors of cardiovascular disease. Arterial displacement was measured from TDI, and B-mode and M-mode images of the common carotid artery in the longitudinal plane, and the DC with each method was compared. Linear regression showed a good correlation between all three methods. The results for TDI and B-mode were comparable [(21±10) compared with (21±10)×10-3/kPa respectively; P=not significant], but there were significant differences between TDI and M-mode [(21±10) compared with (31±13)×10-3/kPa respectively; P<0.0001] and between B-mode and M-mode [(21±10) compared with (31±13)×10-3/kPa respectively; P<0.0001]. Similarly, Bland–Altman analysis showed the least variability in the DC between TDI and B-mode, and there were no significant differences between the average measurements. The TDI DC also had the lowest paired difference for inter-observer variability [(-0.1±1.1)×10-3/kPa; P=not significant]. In conclusion, the results of the present study suggest that TDI of the carotid arteries is feasible, comparable with B-mode measurements, more robust than M-mode and less variable than the other methods.
Keyword Arterial elasticity
Blood pressure
Cardiovascular risk
Distensibility coefficient
Tissue Doppler imaging (TDI)
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Created: Tue, 16 Sep 2008, 11:44:27 EST by Denise Wilson on behalf of School of Medicine