Development of a sufficient design for parameter estimation of fluconazole population pharmacokinetics in HIV patients

Roos, J. F., Tett, S. E., Kirkpatrick, C. M. J. and Duffull, S. B. (2007). Development of a sufficient design for parameter estimation of fluconazole population pharmacokinetics in HIV patients. In: PAGANZ 07: Population Approach Group in Australia & New Zealand, Singapore, (). 13-15 February 2007.


Author Roos, J. F.
Tett, S. E.
Kirkpatrick, C. M. J.
Duffull, S. B.
Title of paper Development of a sufficient design for parameter estimation of fluconazole population pharmacokinetics in HIV patients
Conference name PAGANZ 07: Population Approach Group in Australia & New Zealand
Conference location Singapore
Conference dates 13-15 February 2007
Publisher Population Approach Group in Australia and New Zealand
Publication Year 2007
Sub-type Oral presentation
Language eng
Formatted Abstract/Summary
Introduction: Fluconazole (FCZ) is an antifungal drug commonly used in HIV patients. A clinician suspected low concentrations of FCZ in HIV patients, which could be due to saturable input (low bioavailability) or nonlinear disposition of the drug. In contrast, the literature suggests that FCZ concentrations are increased in HIV patients. A study found in the literature was undertaken to address this question. However, this study protocol is characterized by a very intensive sampling schedule with a total of 1440 samples from 20 HIV patients.

Conclusions: The optimised design (D1) presented in this study illustrates that cost-effective studies that provide acceptable parameter precision are achievable even when there is considerable uncertainty in the model and parameter space.
Subjects EX
1117 Public Health and Health Services
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Abstract No. 1060

Document type: Conference Paper
Collection: School of Pharmacy Publications
 
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Created: Wed, 03 Sep 2008, 09:19:58 EST by Linda Mclean on behalf of Faculty Of Health Sciences