Cancer incidence and mortality in a New Zealand community potentially exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin from 2,4,5-trichlorophenoxyacetic acid manufacture

Read, Deborah, Wright, Craig, Weinstein, Philip and Borman, Barry (2007) Cancer incidence and mortality in a New Zealand community potentially exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin from 2,4,5-trichlorophenoxyacetic acid manufacture. Australian and New Zealand Journal of Public Health, 31 1: 13-18. doi:10.1111/j.1467-842X.2007.tb00883.x


Author Read, Deborah
Wright, Craig
Weinstein, Philip
Borman, Barry
Title Cancer incidence and mortality in a New Zealand community potentially exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin from 2,4,5-trichlorophenoxyacetic acid manufacture
Journal name Australian and New Zealand Journal of Public Health   Check publisher's open access policy
ISSN 1326-0200
1753-6405
Publication date 2007-02
Sub-type Article (original research)
DOI 10.1111/j.1467-842X.2007.tb00883.x
Volume 31
Issue 1
Start page 13
End page 18
Total pages 6
Place of publication Richmond, Vic., Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Formatted abstract
Objective: To investigate whether the rates of all cancers and four cancers (soft tissue sarcoma, non-Hodgkin's lymphoma, Hodgkin's disease and chronic lymphocytic leukaemia) associated with dioxin exposure are higher in New Plymouth, the site of a former 2, 4, 5-T manufacturing plant, than for the rest of New Zealand.
Methods:
Analysis of 1970–2001 cancer data from the New Zealand Cancer Registry was undertaken for New Plymouth and the rest of New Zealand.
Results:
There is no evidence of an increased cancer risk apart from one period (1970-74), which falls partly outside the 1962–1987 manufacturing period if 10-year latency is assumed. For 1970-74, there was an elevated risk for all cancer incidence (SIR=111, 95% CI 104–119), and for two of the four specific cancers that are associated with dioxin exposure (non-Hodgkin's lymphoma SIR=175, 95% CI 121–246 and chronic lymphocytic leukaemia SIR=251, 95% CI 144–408).
Conclusions and Implications:
The results do not suggest an increased cancer risk among the New Plymouth population related to the period of 2, 4, 5-T manufacture, although the study's limitations mean the possibility of an undetectable small elevation in cancer risk cannot be excluded. Although TCDD exposure in the first few years of 2, 4, 5-T manufacture may have contributed to cancer incidence in 1970-74, unknown exposure(s) before the start of 2, 4, 5-T manufacture and chance are also possible explanations.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Created: Thu, 28 Aug 2008, 18:14:36 EST