Phytoestrogens and indicators of breast cancer prognosis

Ha, Tam C., Lyons-Wall, Philippa M., Moore, Douglas E., Tattam, Bruce N., Boyages, John, Ung, Owen A. and Taylor, Richard J. (2006) Phytoestrogens and indicators of breast cancer prognosis. Nutrition and Cancer, 56 1: 3-10. doi:10.1207/s15327914nc5601_2

Author Ha, Tam C.
Lyons-Wall, Philippa M.
Moore, Douglas E.
Tattam, Bruce N.
Boyages, John
Ung, Owen A.
Taylor, Richard J.
Title Phytoestrogens and indicators of breast cancer prognosis
Journal name Nutrition and Cancer   Check publisher's open access policy
ISSN 0163-558;1532-7914
Publication date 2006
Sub-type Article (original research)
DOI 10.1207/s15327914nc5601_2
Volume 56
Issue 1
Start page 3
End page 10
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Routledge
Language eng
Subject 11 Medical and Health Sciences
1112 Oncology and Carcinogenesis
Abstract Breast cancer incidence is lower and survival is longer in Asian women residing in Japan, China, or the Philippines than Caucasian women residing in the United States. Phytoestrogen intake has been examined as a possible reason for the disparity in breast cancer incidence and survival. This study examined the association between phytoestrogen intake prior to diagnosis of breast cancer and indicators of breast cancer prognosis (tumor size, estrogen and progesterone receptor status, histological grade, lymphovascular invasion, nodal spread, and stage) in 128 women, aged 40-79 yr, newly diagnosed with invasive breast cancer. After controlling for significant confounding factors, higher intakes of phytoestrogens were associated with favorable indicators of breast cancer. In women with higher intakes of phytoestrogens, there was a 32% reduction in the odds of being diagnosed with any stage of cancer other than stage 1 (95% confidence interval, CI = 0.49-0.93; P = 0.02), a 38% reduction in odds of being diagnosed with positive lymphovascular invasion (95% CI = 0.40-0.95; P = 0.03), and a 66% increase in the odds of being diagnosed with a positive progesterone receptor (95% CI = 1.06-2.58; P = 0.03). We conclude that phytoestrogen intake prior to diagnosis may improve prognosis of breast cancer.
Keyword Adult
Anticarcinogenic Agents/ administration & dosage
Breast Neoplasms/ epidemiology/mortality/pathology
Confidence Intervals
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
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Created: Thu, 28 Aug 2008, 17:52:48 EST