Drugs and alcohol: Treating and preventing abuse, addiction and their medical consequences

Volkow, N. D. and Li, T. K. (2005) Drugs and alcohol: Treating and preventing abuse, addiction and their medical consequences. Pharmacology & Therapeutics, 108 1: 3-17. doi:10.1016/j.pharmthera.2005.06.021


Author Volkow, N. D.
Li, T. K.
Title Drugs and alcohol: Treating and preventing abuse, addiction and their medical consequences
Journal name Pharmacology & Therapeutics   Check publisher's open access policy
ISSN 0163-7258
Publication date 2005
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.pharmthera.2005.06.021
Volume 108
Issue 1
Start page 3
End page 17
Total pages 15
Place of publication [London, U.K.]
Publisher Elsevier
Language eng
Subject 1115 Pharmacology and Pharmaceutical Sciences
Abstract Recent advances in the fields of genetics, molecular biology, behavioral neuropharmacology, and brain imaging have dramatically changed our understanding of the addictive process and why relapse occurs even in the face of catastrophic consequences. Addiction is now recognized as a chronic brain disease that involves complex interactions between repeated exposure to drugs, biological (i.e., genetic and developmental), and environmental (i.e., drug availability, social, and economic variables) factors. Its treatment, therefore, requires, in general, not only a long-term intervention but also a multipronged approach that addresses the psychiatric, medical, legal, and social consequences of addiction. Also, because addiction usually starts in adolescence or early adulthood and is frequently comorbid with mental illness, we need to expand our treatment interventions in this age group both for substance abuse and psychiatric disorders. Published by Elsevier Inc.
Keyword addiction
dopamine
prevention
treatment
mental illness
adolescence
SUBSTANCE USE DISORDERS
Gamma-vinyl gaba
United States
Human Brain
Follow-up
contingency management
Outpatient treatments
cost- effectiveness
Nonhuman-primates
Prenatal cocaine exposure
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Public Health Publications
 
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Created: Thu, 28 Aug 2008, 17:48:52 EST