Nuclear Factor I Gene Expression in the Developing Forebrain

Plachez, Celine, Lindwall, Charlotta, Sunn, Nana, Piper, Michael, Moldrich, Randal X., Campbell, Christine E., Osinski, Jason M., Gronostajski, Richard M. and Richards, Linda J. (2008) Nuclear Factor I Gene Expression in the Developing Forebrain. Journal of Comparative Neurology, 508 3: 385-401. doi:10.1002/cne.21645


Author Plachez, Celine
Lindwall, Charlotta
Sunn, Nana
Piper, Michael
Moldrich, Randal X.
Campbell, Christine E.
Osinski, Jason M.
Gronostajski, Richard M.
Richards, Linda J.
Title Nuclear Factor I Gene Expression in the Developing Forebrain
Journal name Journal of Comparative Neurology   Check publisher's open access policy
ISSN 1096-9861
0021-9967
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1002/cne.21645
Volume 508
Issue 3
Start page 385
End page 401
Total pages 17
Editor Clifford B Saper
Place of publication Hoboken, N.J.
Publisher John Wiley & Sons Inc.
Collection year 2009
Language eng
Subject C1
110903 Central Nervous System
110902 Cellular Nervous System
920111 Nervous System and Disorders
Abstract Three members of the Nuclear Factor I (Nfi) gene family of transcription factors; Nfia, Nfib, and Nfix are highly expressed in the developing mouse brain. Nfia and Nfib knockout mice display profound defects in the development of midline glial populations and the development of forebrain commissures (das Neves et al. [1999] Proc Natl Acad Sci U S A 96:11946–11951; Shu et al. [2003] J Neurosci 23:203–212; Steele-Perkins et al. [2005] Mol Cell Biol 25:685–698). These findings suggest that Nfi genes may regulate the substrate over which the commissural axons grow to reach targets in the contralateral hemisphere. However, these genes are also expressed in the cerebral cortex and, thus, it is important to assess whether this expression correlates with a cell-autonomous role in cortical development. Here we detail the protein expression of NFIA and NFIB during embryonic and postnatal mouse forebrain development. We find that both NFIA and NFIB are expressed in the deep cortical layers and subplate prenatally and display dynamic expression patterns postnatally. Both genes are also highly expressed in the developing hippocampus and in the diencephalon. We also find that principally neither NFIA nor NFIB are expressed in callosally projecting neurons postnatally, emphasizing the role for midline glial cell populations in commissure formation. However, a large proportion of laterally projecting neurons express both NFIA and NFIB, indicating a possible cell-autonomous role for these transcription factors in corticospinal neuron development. Collectively, these data suggest that, in addition to regulating the formation of axon guidance substrates, these genes also have cell-autonomous roles in cortical development. J. Comp. Neurol. 508:385–401, 2008. © 2008 Wiley-Liss, Inc.
Keyword Cortical Development
Hippocampus
Midline Glia
Transcription Factor
Cortical Layers
Telencephalon
Nfi
Q-Index Code C1
Q-Index Status Confirmed Code

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 46 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 46 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 30 Jul 2008, 02:21:56 EST