Targeting ischemic brain injury with intravenous immunoglobulin

Arumugam, Thiruma V., Selvaraj, Pradeep K., Woodruff, Trent M. and Mattson, Mark P. (2008) Targeting ischemic brain injury with intravenous immunoglobulin. Expert Opinion on Therapeutic Targets, 12 1: 19-29. doi:10.1517/14728222.12.1.19


Author Arumugam, Thiruma V.
Selvaraj, Pradeep K.
Woodruff, Trent M.
Mattson, Mark P.
Title Targeting ischemic brain injury with intravenous immunoglobulin
Journal name Expert Opinion on Therapeutic Targets   Check publisher's open access policy
ISSN 1472-8222
1744-7631
Publication date 2008-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1517/14728222.12.1.19
Open Access Status
Volume 12
Issue 1
Start page 19
End page 29
Total pages 11
Place of publication London, United Kingdom
Publisher Ashley Publications
Collection year 2009
Language eng
Subject 0304 Medicinal and Biomolecular Chemistry
C1
070705 Veterinary Immunology
110399 Clinical Sciences not elsewhere classified
Formatted abstract
Background:
Intravenous immunoglobulin (IVIG) is a therapeutic modality approved for the treatment of autoimmune disorders.

Objective:
This review discusses how IVIG can prevent brain damage following ischemic stroke and discuss the potential mechanisms of action.

Methods:
Medline and the world wide web were searched and the relevant literature was classified under the following categories: IVIG, IVIG mechanism of action, and ischemic stroke injury mechanisms.

Results/conclusion:

Brain ischemia induces an inflammatory response that contributes to neuronal cell death. Because of its ability to block multiple molecular events, IVIG may have particularly strong neuroprotective action against ischemic brain injury. In light of the extensive clinical experience with IVIG for other indications, development of clinical trials to evaluate the use of IVIG in human stroke patients are warranted.
Keyword apoptosis
cerebral ischemia
complement
intravenous immunoglobulin
ischemic stroke
T lymphocytes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2009 Higher Education Research Data Collection
School of Biomedical Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 19 times in Scopus Article | Citations
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Created: Tue, 29 Jul 2008, 16:16:03 EST