Tumours in mice induced by exposure to sodium arsenate in drinking water

Ng, J. C., Seawright, A. A., Qi, L., Garnett, C. M., Chiswell, B. and Moore, M. (1999). Tumours in mice induced by exposure to sodium arsenate in drinking water. In: Willard R. Chappel, Charles O. Abernathy and Rebecca L. Calderon, Arsenic exposure and health effects III: Proceedings of the Third International Conference on Arsenic Exposure and Health Effects. Third International Conference on Arsenic Exposure and Health Effects, San Diego, CA, United States, (217-223). 12–15 July 1998. doi:10.1016/B978-008043648-7/50025-X


Author Ng, J. C.
Seawright, A. A.
Qi, L.
Garnett, C. M.
Chiswell, B.
Moore, M.
Title of paper Tumours in mice induced by exposure to sodium arsenate in drinking water
Conference name Third International Conference on Arsenic Exposure and Health Effects
Conference location San Diego, CA, United States
Conference dates 12–15 July 1998
Proceedings title Arsenic exposure and health effects III: Proceedings of the Third International Conference on Arsenic Exposure and Health Effects
Place of Publication Amsterdam, Netherlands
Publisher Elsevier
Publication Year 1999
Sub-type Fully published paper
DOI 10.1016/B978-008043648-7/50025-X
ISBN 9780080436487
Editor Willard R. Chappel
Charles O. Abernathy
Rebecca L. Calderon
Start page 217
End page 223
Total pages 7
Language eng
Formatted Abstract/Summary
Groups of 90 female C57Bl/6J mice and 140 female metallothioein knock-out transgenic (MT) mice were given drinking water containing sodium arsenate, 500 μg arsenic (As)/L ad libitum for up to 26 months. The average intake of As by the test groups was estimated to be approximately 2.0 μg As per day or a daily dose rate of 0.07 mg As/kg body weight for a 30 g mouse. For a mouse surviving two years, it would have consumed about 1.46 mg of As. Preliminary findings indicate that 37/90 (41.1%) C57Bl/6J and 37/140 (26.4%) MT test mice had one or more tumors. The incidence of which involved the gastrointestinal tract (C57Bl/6J=14.4%, MT=12.9%), lungs (17.8%, 7.1%), liver (7.8%, 5%), spleen (3.3%, 0.7%), bone (2.2%, 0%), skin (3.3%, 1.4%), reproductive system (3.3%, 5%), and eye (1.1%, 0%). No tumors were observed in the control groups.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
Collection: National Research Centre for Environmental Toxicology Publications
 
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Created: Fri, 06 Jun 2008, 22:26:57 EST