Deoxycylindrospermopsin, an analog of cylindrospermopsin from Cylindrospermopsis raciborskii

Norris, RL, Pierens, G, Shaw, GR, Smith, MJ, Chiswell, RK, Seawright, AA and Moore, MR (1999) Deoxycylindrospermopsin, an analog of cylindrospermopsin from Cylindrospermopsis raciborskii. Environmental Toxicology, 14 1: 163-165. doi:10.1002/(SICI)1522-7278(199902)14:1<163::AID-TOX21>3.0.CO;2-V

Author Norris, RL
Pierens, G
Shaw, GR
Smith, MJ
Chiswell, RK
Seawright, AA
Moore, MR
Title Deoxycylindrospermopsin, an analog of cylindrospermopsin from Cylindrospermopsis raciborskii
Journal name Environmental Toxicology   Check publisher's open access policy
ISSN 1520-4081
Publication date 1999
Sub-type Article (original research)
DOI 10.1002/(SICI)1522-7278(199902)14:1<163::AID-TOX21>3.0.CO;2-V
Volume 14
Issue 1
Start page 163
End page 165
Total pages 3
Place of publication New York
Publisher John Wiley & Sons
Collection year 1999
Language eng
Subject C1
321299 Public Health and Health Services not elsewhere classified
730200 Public Health
Abstract Cylindrospermopsin (CYN) is a hepatotoxic alkaloid found in the blue-green alga Cylindrospermopsis raciborskii (C. raciborskii). Data indicating CYN alone does not account for the toxicity of freeze dried cultures of C. raciborskii have been presented recently. In an attempt to explain these data, we have purified and characterized the structure of an analog of CYN, deoxycylindrospermopsin (deoxy-CYN). Three mice dosed intraperitoneally (IP) with 0.8 mg/kg of deoxy-CYN showed no toxicity after 5 days. Comparison with the toxicity of CYN (5 day median lethal dose approximately 0.2 mg/kg IF) and its relative abundance in C. raciborskii suggest deoxy-CYN does not contribute significantly to the toxicity of C. raciborskii. The additional toxicity of freeze dried C. raciborskii over pure CYN, therefore, remains unexplained. (C) 1999 by John Wiley & Sons, Inc.
Keyword Environmental Sciences
Water Resources
Cylindrospermopsis Raciborskii
Blue-green Alga
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
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Created: Tue, 10 Jun 2008, 15:32:41 EST