Leptin levels are suppressed in primary aldosteronism

Torpy, D. J., Bornstein, S. R., Taylor, W., Tauchnitz, R. and Gordon, R. D. (1999) Leptin levels are suppressed in primary aldosteronism. Hormone and Metabolic Research, 31 9: 533-536. doi:10.1055/s-2007-978789

Author Torpy, D. J.
Bornstein, S. R.
Taylor, W.
Tauchnitz, R.
Gordon, R. D.
Title Leptin levels are suppressed in primary aldosteronism
Journal name Hormone and Metabolic Research   Check publisher's open access policy
ISSN 0018-5043
Publication date 1999-09
Sub-type Article (original research)
DOI 10.1055/s-2007-978789
Volume 31
Issue 9
Start page 533
End page 536
Total pages 4
Place of publication New York, NY, U.S.A.
Publisher Georg Thieme Verlag Stuttgart
Collection year 1999
Language eng
Subject C1
730105 Endocrine organs and diseases (incl. diabetes)
321004 Endocrinology
1103 Clinical Sciences
Formatted abstract
Primary aldosteronism is associated with hypertension secondary to salt and water retention, hypokalemia and impaired insulin secretion with glucose intolerance in some patients. The secretion of leptin, a hormone produced by adipocytes, may be altered by reduced insulin secretion in primary aldosteronism. We measured plasma leptin approximately 3 months before and 3 months after curing of primary aldosteronism in 18 patients (12 male, 6 female, body mass index 29.1 ± 4.4, mean ± SD). Patients were treated by unilateral laparoscopic adrenalectomy to remove an aldosterone-producing adenoma. There was a 46% postoperative increase in plasma leptin concentrations from 6.65 ± 0.81 to 9.68 ± 1.50 ng/ml (P = 0.004), despite a non-significant fall in body mass index. Plasma leptin was noted to increase after adrenalectomy in 16 of the 18 patients. The patients also had improved blood pressure and a significant increase in plasma potassium post-operatively. It is proposed that increased insulin secretory capacity associated with correction of negative potassium balance may account for the increase in plasma leptin after curing primary aldosteronism. Further studies are indicated to identify the mechanism of plasma leptin suppression in primary aldosteronism.
Keyword Endocrinology & Metabolism
Plasma Leptin
Insulin Sensitivity
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Tue, 10 Jun 2008, 14:58:37 EST