Responses of the growth hormone (GH) and insulin-like growth factor axis to exercise, GH administration, and GH withdrawal in trained adult males: A potential test for GH abuse in sport

Wallace, Jennifer D., Cuneo, Ross C., Baxter, Robert, Ørskov, Hans, Keay, Nicola, Pentecost, Claire, Dall, Rolf, Rosén, Thord, Jørgensen, Jens Otto, Cittadini, Antonio, Longobardi, Salvatore, Sacca, Luigi, Christiansen, Jens Sandahl, Bengtsson, Bengt-Åke and Sönksen, Peter H. (1999) Responses of the growth hormone (GH) and insulin-like growth factor axis to exercise, GH administration, and GH withdrawal in trained adult males: A potential test for GH abuse in sport. Journal of Clinical Endocrinology & Metabolism, 84 10: 3591-3601. doi:10.1210/jc.84.10.3591


Author Wallace, Jennifer D.
Cuneo, Ross C.
Baxter, Robert
Ørskov, Hans
Keay, Nicola
Pentecost, Claire
Dall, Rolf
Rosén, Thord
Jørgensen, Jens Otto
Cittadini, Antonio
Longobardi, Salvatore
Sacca, Luigi
Christiansen, Jens Sandahl
Bengtsson, Bengt-Åke
Sönksen, Peter H.
Title Responses of the growth hormone (GH) and insulin-like growth factor axis to exercise, GH administration, and GH withdrawal in trained adult males: A potential test for GH abuse in sport
Journal name Journal of Clinical Endocrinology & Metabolism   Check publisher's open access policy
ISSN 0021-972X
1945-7197
0013-7227
0888-8809
2150-5810
Publication date 1999-10
Sub-type Article (original research)
DOI 10.1210/jc.84.10.3591
Volume 84
Issue 10
Start page 3591
End page 3601
Total pages 11
Place of publication Bethesda, MA, U.S.A.
Publisher Endocrine Society
Collection year 1999
Language eng
Subject C1
730105 Endocrine organs and diseases (incl. diabetes)
321004 Endocrinology
Formatted abstract
GH abuse by elite athletes is currently undetectable. To define suitable markers of GH doping, we assessed the effects of acute exercise, GH administration, and GH withdrawal on the GH/insulin-like growth factor (IGF) axis in athletic adult males. Acute endurance-type exercise increased serum GH, GH binding protein (GHBP), total IGF-I, IGF-binding protein (IGFBP)-3, and acid-labile subunit (ALS), each peaking at the end of exercise. IGFBP-1 increased after exercise was completed. Free IGF-I did not change with exercise. Recombinant human GH treatment (0.15 IU/kg.day) for 1 week increased serum total IGF-I, IGFBP-3, and ALS, exaggerating the responses to exercise. IGFBP-2 and IGFBP-1 were trivially suppressed. After GH withdrawal, the GH response to identical exercise was suppressed. Total IGF-I, IGFBP-3, and ALS returned to baseline over 3-4 days. In summary, 1) acute exercise transiently increased all components of the IGF-I ternary complex, possibly due to mobilization of preformed intact complexes; 2) GH pretreatment augmented the exercise-induced changes in ternary complexes; 3) postexercise IGFBP-1 increments may protect against delayed onset hypoglycemia; 4) serum total IGF-I, IGFBP-3, and ALS may be suitable markers of GH abuse; and 5) differences in disappearance times altered the sensitivity of each marker for detecting GH abuse.
Copyright © 1999 by The Endocrine Society
Keyword Endocrinology & Metabolism
Factor-binding Protein-1
Serum Igf-i
Tissue Distribution
Molecular-distribution
Nutritional Regulation
Cellular-localization
Prolonged Exercise
Body-composition
Rapid Clearance
Healthy-men
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 10 Jun 2008, 14:33:49 EST