Effects of exercise on lipoprotein(a)

Mackinnon, Laurel T. and Hubinger, Lyle M. (1999) Effects of exercise on lipoprotein(a). Sports Medicine, 28 1: 11-24. doi:10.2165/00007256-199928010-00002

Author Mackinnon, Laurel T.
Hubinger, Lyle M.
Title Effects of exercise on lipoprotein(a)
Journal name Sports Medicine   Check publisher's open access policy
ISSN 0112-1642
Publication date 1999-07
Sub-type Article (original research)
DOI 10.2165/00007256-199928010-00002
Volume 28
Issue 1
Start page 11
End page 24
Total pages 14
Place of publication Auckland, N.Z.
Publisher ADIS Press
Collection year 1999
Language eng
Subject C1
321401 Exercise Physiology
730106 Cardiovascular system and diseases
Formatted abstract
Lipoprotein(a) [Lp(a)] is a unique lipoprotein complex in the blood. At high levels (>30 mg/dl), Lp(a) is considered an independent risk factor for cardiovascular diseases. Serum Lp(a) levels are largely genetically determined, remain relatively constant within a given individual, and do not appear to be altered by factors known to influence other lipoproteins (e.g. lipid-lowering drugs, dietary modification and change in body mass). Since regular exercise is associated with favourable changes in lipoproteins in the blood, recent attention has focused on whether serum Lp(a) levels are also influenced by physical activity. Population and cross-sectional studies consistently show a lack of association between serum Lp(a) levels and regular moderate physical activity.Moreover, exercise intervention studies extending from 12 weeks to 4 years indicate that serum Lp(a) levels do not change in response to moderate exercise training, despite improvements in fitness level and other lipoprotein levels in the blood. However, recent studies suggest the possibility that serumLp(a) levels may increase in response to intense load-bearing exercise training, such as distance running or weight lifting, over several months to years. Cross-sectional studies have reported abnormally high serum Lp(a) levels in experienced distance runners and body builders who train for 2 to 3 hours each day. However, the possible confounding influence of racial or ethnic factors in these studies cannot be discounted.

Recent intervention studies also suggest that 9 to 12months of intense exercise training may elevate serum Lp(a) levels. However, these changes are generally modest (10 to 15%) and, in most individuals, serum Lp(a) levels remain within the recommended range. It is unclear whether increased serum Lp(a) levels after intense exercise training are of clinical relevance, and whether certain Lp(a) isoforms are more sensitive to the effects of exercise training. Since elevation of both low density lipoprotein cholesterol (LDL-C) and Lp(a) levels in the blood exerts a synergistic effect on cardiovascular disease risk, attention should focus on changing lifestyle factors to decrease LDL-C (e.g. dietary intervention) and increase high density lipoprotein cholesterol (e.g. exercise) levels in the blood.
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Keyword Sport Sciences
Middle-aged Males
Serum Lipoprotein(a)
Lp(a) Lipoprotein
Risk Factor
Coronary Atherosclerosis
Sedentary Controls
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Human Movement and Nutrition Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 20 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 27 times in Scopus Article | Citations
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Created: Tue, 10 Jun 2008, 14:14:55 EST