Eighth international workshop on ataxia-telangiectasia (ATW8)

Lavin, Martin F., Concannon, Patrick and Gatti, Richard A. (1999) Eighth international workshop on ataxia-telangiectasia (ATW8). Cancer Research, 59 15: 3845-3849.

Author Lavin, Martin F.
Concannon, Patrick
Gatti, Richard A.
Title Eighth international workshop on ataxia-telangiectasia (ATW8)
Journal name Cancer Research   Check publisher's open access policy
ISSN 0008-5472
Publication date 1999-08-01
Sub-type Discussion - responses, round table/panel discussions, Q&A, reply
Volume 59
Issue 15
Start page 3845
End page 3849
Total pages 5
Place of publication Philadelphia, PA, U.S.A.
Publisher American Association for Cancer Research
Collection year 1999
Language eng
Subject C4
730107 Inherited diseases (incl. gene therapy)
320304 Medical Biochemistry - Nucleic Acids
Formatted abstract
ATW8 was a unique opportunity to review the complex and growing field of ataxia-telangiectasia (A-T) research and to cross-fertilize ideas for new experimental designs. A-T biology now encompasses human and mouse neurology, neurobiology, immunology, radiobiology, cell signalling, cell cycle checkpoints, gametogenesis, and oncogenesis, as well as radiotherapy, cancer epidemiology, premature aging, cytogenetics, and DNA repair mechanisms. By an as yet undetermined mechanism, the ATM protein appears to sense double strand breaks (DSB) during meiosis or mitosis, or breaks consequent to the damage of free radicals which are generated during the metabolism of food. As a protein kinase, ATM then directly phosphorylates p53 and interacts with many other molecules involved in homologous and nonhomologous DSB repair, as well as in cell signalling. Some of these molecule targets include: c-ab1, ATR, chk-1, chk-2, RPA, BRCA1, BRCA2, NFκB/IκBα, β-adaptin, and perhaps ATM itself. Thus, ATM is a “hierarchical kinase,” initiating many pathways simultaneously. Parallel sessions or longer meetings will clearly be necessary for future A-T workshops.
Q-Index Code C4
Additional Notes Published under "Meeting Report". Report on the meeting held at Las Vegas, Nevada, USA, February 14-17, 1999.

Document type: Journal Article
Sub-type: Discussion - responses, round table/panel discussions, Q&A, reply
Collection: UQ Centre for Clinical Research Publications
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Created: Tue, 10 Jun 2008, 14:13:20 EST