Mycobacterium avium complex causing endobronchial disease in AIDS patients after partial immune restoration

Bartley, P. B., Allworth, A. M. and Eisen, D. P. (1999) Mycobacterium avium complex causing endobronchial disease in AIDS patients after partial immune restoration. International Journal of Tuberculosis and Lung Disease, 3 12: 1132-1136.


Author Bartley, P. B.
Allworth, A. M.
Eisen, D. P.
Title Mycobacterium avium complex causing endobronchial disease in AIDS patients after partial immune restoration
Journal name International Journal of Tuberculosis and Lung Disease   Check publisher's open access policy
ISSN 1027-3719
Publication date 1999
Sub-type Article (original research)
Volume 3
Issue 12
Start page 1132
End page 1136
Total pages 5
Place of publication Paris, France
Publisher Int. Union Against Tuberculosis Lung Disease
Collection year 1999
Language eng
Subject C3
321010 Infectious Diseases
730101 Infectious diseases
Formatted abstract
OBJECTIVE: To report the development of an unusual manifestation of pulmonary Mycobacterium avium complex (MAC) infection in two patients with the acquired immune-deficiency syndrome (AIDS) after the commencement of combination antiretroviral chemotherapy.

PATIENTS: Two Caucasian males with human immunodeficiency virus (HIV) infection and CD4 lymphocyte counts <0.05 × 109/l and with plasma HIV polymerase chain reaction (PCR) >100 000 copies/ml who were commenced on combination antiretroviral chemotherapy including a protease inhibitor.

RESULTS: Both patients developed endobronchial polypoid tumours within two months of commencing antiretroviral chemotherapy. Histology demonstrated granuloma formation and acid-fast bacilli. Tissue from both patients grew M. avium. Both patients achieved significant suppression of viral replication and had significantly improved CD4 lymphocyte counts. Both required anti-mycobacterial therapy.

CONCLUSIONS: Endobronchial polypoid tumours due to MAC infection have only been described in HIV-infected patients receiving antiretroviral chemotherapy. A degree of restored immunity is implicated in the pathogenesis of this unusual disease.
Keyword Infectious Diseases
Respiratory System
Mac
Aids
Immune Restoration
Hiv-infected Patients
Antiretroviral Therapy
Zidovudine
Initiation
Q-Index Code C3

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 10 Jun 2008, 13:27:09 EST