Replicon-based vectors of positive strand RNA viruses.

Khromykh, A. A. (2000) Replicon-based vectors of positive strand RNA viruses.. Current Opinion in Molecular Therapeutics, 2 5: 555-569.

Author Khromykh, A. A.
Title Replicon-based vectors of positive strand RNA viruses.
Journal name Current Opinion in Molecular Therapeutics   Check publisher's open access policy
ISSN 1464-8431
Publication date 2000-10
Sub-type Article (original research)
Volume 2
Issue 5
Start page 555
End page 569
Total pages 15
Place of publication London, U.K..
Publisher Thomson Current Drugs
Collection year 2000
Language eng
Subject C1
060506 Virology
Abstract Vectors based on self-replicating RNAs (replicons) of positive strand RNA viruses are becoming powerful tools for gene expression in mammalian cells and for the development of novel antiviral and anticancer vaccines. A relatively small genome size and simple procedure allow rapid generation of recombinants. Cytoplasmic RNA amplification eliminates nuclear involvement and leads to extremely high levels of gene expression, and continuous synthesis of double stranded RNA results in induction of enhanced immune responses, making these vectors unique among other gene expression systems. Both cytopathic replicon vectors allowing short-term transient expression, and non-cytopathic replicon vectors allowing long-term stable expression, are now available with the choice of vector depending on particular applications.
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 46 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 10 Jun 2008, 13:23:10 EST