Boundary lubrication in vivo

Hills, B. A. (2000) Boundary lubrication in vivo. Proceedings of the Institute of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 214 1: 83-94. doi:10.1243/0954411001535264

Author Hills, B. A.
Title Boundary lubrication in vivo
Formatted title
Boundary lubrication in vivo
Journal name Proceedings of the Institute of Mechanical Engineers, Part H: Journal of Engineering in Medicine   Check publisher's open access policy
ISSN 0954-4119
Publication date 2000
Sub-type Article (original research)
DOI 10.1243/0954411001535264
Volume 214
Issue 1
Start page 83
End page 94
Total pages 12
Place of publication London, U.K.
Publisher Professional Engineering Publishing
Collection year 2000
Language eng
Subject C3
321028 Rheumatology and Arthritis
730114 Skeletal system and disorders (incl. arthritis)
Formatted abstract
Evidence is reviewed for the concept that the body employs essentially the same lubrication system in many sites in the body where tissues slide over each other with such ease. This system consists of fluid adjacent to surfaces coated with an oligolamellar lining of surface-active phospholipid (SAPL) acting as a back-up boundary lubricant wherever the fluid film fails to support the load-a likely event at physiological velocities. Particular attention is paid to the load-bearing joints, where the issue of identifying the vital active ingredient in synovial fluid is reviewed, coming down-perhaps predictably-in favour of SAPL. It is also explained how Lubricin and hyaluronic acid (HA) could have 'carrier' functions for the highly insoluble SAPL, while HA has good wetting properties needed to promote hydrodynamic lubrication of a very hydrophobic articular surface by an aqueous fluid wherever the load permits.

In addition to friction and wear, release is included as another major role of boundary lubricants, especially relevant in environments where proteins are found, many having adhesive properties. The discussion is extended to a mention of the lubrication of prosthetic implants and to disease states where a deficiency of boundary lubricant is implicated, particular attention being paid to osteoarthritis.
© IMechE 2000
Keyword Engineering, Biomedical
Engineering, Mechanical
Boundary Lubrication
Prosthetic Implants
Surface-active Phospholipid
Articular Surfaces
Q-Index Code C3

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 135 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 156 times in Scopus Article | Citations
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Created: Tue, 10 Jun 2008, 13:22:30 EST