The alpha-synuclein gene and Parkinson disease in a Chinese population

Chan, D. K. Y., Mellick, G., Cai, H., Wang, X. L., Ng, P. W., Pang, C. P., Woo, J. and Kay, R. (2000) The alpha-synuclein gene and Parkinson disease in a Chinese population. Archives of Neurology, 57 4: 501-503. doi:10.1001/archneur.57.4.501

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Author Chan, D. K. Y.
Mellick, G.
Cai, H.
Wang, X. L.
Ng, P. W.
Pang, C. P.
Woo, J.
Kay, R.
Title The alpha-synuclein gene and Parkinson disease in a Chinese population
Journal name Archives of Neurology   Check publisher's open access policy
ISSN 0003-9942
Publication date 2000
Sub-type Article (original research)
DOI 10.1001/archneur.57.4.501
Open Access Status File (Publisher version)
Volume 57
Issue 4
Start page 501
End page 503
Total pages 3
Place of publication Chicago
Publisher American Medical Association
Collection year 2000
Language eng
Abstract Objective: To study the Ala53Thr and Ala30Pro mutations of the alpha-synuclein gene in a large number of Chinese patients with Parkinson disease (PD) as well as controls. Methods: We recruited 183 Chinese patients with sporadic PD, 17 with younger-onset PD (onset age <50 years), and 7 with PD and a positive family history as well as 227 unaffected Chinese control subjects from the outpatient departments of 2 major hospitals in Hong Kong. All subjects were assessed for the the diagnosis of PD by a consultant neurologist or geriatrician. Subjects were interviewed with a standard questionnaire that also questioned for family history. Venous blood samples were obtained from the subjects and genomic DNA was extracted and studied for the presence of Ala53Thr mutation in exon 4 and Ala30Pro mutation in exon 3 of the alpha-synuclein gene using a polymerase chain reaction restriction fragment length polymorphism method. Results: None of the Chinese PD patients or controls had either the Ala53Thr (exon 4) or Ala30Pro (exon 3) mutation of the alpha-synuclein gene. Conclusion: We failed to discover Ala53Thr or Ala30Pro mutations in a large number of Chinese patients with PD and control subjects, adding to the emerging consensus that variations in the alpha-synuclein gene are associated with PD in few families worldwide.
Keyword Clinical Neurology
Mutation
Absence
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 10 Jun 2008, 13:21:21 EST