Hypothesis: Is low prenatal vitamin D a risk-modifying factor for schizophrenia?

McGrath, J. (1999) Hypothesis: Is low prenatal vitamin D a risk-modifying factor for schizophrenia?. Schizophrenia Research, 40 3: 173-177. doi:10.1016/S0920-9964(99)00052-3


Author McGrath, J.
Title Hypothesis: Is low prenatal vitamin D a risk-modifying factor for schizophrenia?
Journal name Schizophrenia Research   Check publisher's open access policy
ISSN 0920-9964
Publication date 1999-01-01
Sub-type Article (original research)
DOI 10.1016/S0920-9964(99)00052-3
Volume 40
Issue 3
Start page 173
End page 177
Total pages 5
Editor H. Nasrallah
L. DeLisi
Place of publication New York
Publisher Elsevier
Collection year 2000
Language eng
Subject C3
321021 Psychiatry
730211 Mental health
Abstract The central nervous system is increasingly being recognised as a target organ for vitamin D via its wide-ranging steroid hormonal effects and via the induction of various proteins such as nerve growth factor. This paper proposes that low maternal vitamin D may impact adversely on the developing foetal brain, leaving the affected offspring at increased risk of adult-onset schizophrenia. The hypothesis can parsimoniously explain diverse epidemiological features of schizophrenia, such as the excess of winter births, increased rates of schizophrenia in dark-skinned migrants to cold climates, the increased rate of schizophrenia births in urban versus rural setting, and the association between prenatal famine and schizophrenia. Studies that will allow rejection of the hypothesis are proposed. (C) 1999 Elsevier Science B.V. All rights reserved.
Keyword Psychiatry
Non-genetic Risk Factors
Schizophrenia
Vitamin D
Medical Inpatients
Hypovitaminosis-d
Asians
London
System
Q-Index Code C3

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 10 Jun 2008, 23:19:07 EST