Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression

Hume, D. A. (2000) Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression. Blood, 96 7: 2323-2328.


Author Hume, D. A.
Title Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression
Journal name Blood   Check publisher's open access policy
ISSN 0006-4971
Publication date 2000-01-01
Sub-type Article (original research)
Volume 96
Issue 7
Start page 2323
End page 2328
Total pages 6
Place of publication Washington, DC
Publisher American Society for Hematology
Collection year 2000
Language eng
Subject C1
270100 Biochemistry and Cell Biology
780105 Biological sciences
1103 Clinical Sciences
Abstract The phenotype of individual hematopoietic cells, like all other differentiated mammalian cells, is determined by selective transcription of a subset of the genes encoded within the genome. This overview summarizes the recent evidence that transcriptional regulation at the level of individual cells is best described in terms of the regulation of the probability of transcription rather than the rate. In this model, heterogeneous gene expression among populations of cells arises by chance, and the degree of heterogeneity is a If unction of the stability of the mRNA and protein products of individual genes. The probabilistic nature of transcriptional regulation provides one explanation for stochastic phenomena, such as stem cell lineage commitment, and monoallelic expression of inducible genes, such as lymphokines and cytokines. (Blood. 2000;96:2323-2328) (C) 2000 by The American Society of Hematology.
Keyword Hematology
Rna-polymerase-ii
Colony-stimulating Factor
Cd4(+) T-cells
Receptor-transgenic Mice
In-vitro
Preinitiation Complex
Phenotype Development
Chromatin Templates
Hematopoietic Stem
Cytokine Phenotype
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 10 Jun 2008, 23:01:20 EST