G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages

Thomas, Gordon R., Costelloe, E. A., Lunn, D. P., Stacey, K. J., Passey, R., McGlinn, E. C., McMorran, B. J., Ahadizadeh, A., Geczy, C. L., Wainwright, B. J. and Hume, D. A. (2000) G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages. The Journal of Immunology, 164 7: 3870-3877.

Author Thomas, Gordon R.
Costelloe, E. A.
Lunn, D. P.
Stacey, K. J.
Passey, R.
McGlinn, E. C.
McMorran, B. J.
Ahadizadeh, A.
Geczy, C. L.
Wainwright, B. J.
Hume, D. A.
Title G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages
Journal name The Journal of Immunology   Check publisher's open access policy
ISSN 0022-1767
1550-6606
Publication date 2000-04
Sub-type Article (original research)
Volume 164
Issue 7
Start page 3870
End page 3877
Total pages 8
Place of publication Maryland, United States
Publisher American Association of Immunologists.
Collection year 2000
Language eng
Subject C1
Abstract The major cause of death in cystic fibrosis (CF) is chronic lung disease associated with persistent infection by the bacterium, Pseudomonas aeruginosa. S100A8, an S-100 calcium-binding protein with chemotactic activity, is constitutively expressed in the lungs and serum of CF patients. Levels of S100A8 mRNA were found to be three to four times higher in the lungs of mice carrying the G551D mutation in CF transmembrane conductance regulator compared with littermate controls. Intravenous injection of bacterial LPS induced S100A8 mRNA in the lung to a greater extent in G551D mice than in wild-type littermates. Localization of S100A8 mRNA and protein in the lung indicate that it is a marker for neutrophil accumulation. Bone marrow-derived macrophages from G551D mice were shown to also exhibit hypersensitivity to LPS, measured by induction of TNF-{alpha}. These results provide evidence that the pathology of CF relates to abnormal regulation of the immune system. Copyright © 2000 by The American Association of Immunologists
Keyword Cystic Fibrosis
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Tue, 10 Jun 2008, 12:58:19 EST