Cylindrospermopsin, A cyanobacterial alkaloid: Evaluation of its toxicologic activity

Shaw, GR, Seawright, AA, Moore, MR and Lam, PKS (2000) Cylindrospermopsin, A cyanobacterial alkaloid: Evaluation of its toxicologic activity. Therapeutic Drug Monitoring, 22 1: 89-92.


Author Shaw, GR
Seawright, AA
Moore, MR
Lam, PKS
Title Cylindrospermopsin, A cyanobacterial alkaloid: Evaluation of its toxicologic activity
Journal name Therapeutic Drug Monitoring   Check publisher's open access policy
Publication date 2000
Sub-type Article
DOI 10.1097/00007691-200002000-00019
Volume number 22
Issue number 1
ISSN 0163-4356
Start page 89
End page 92
Total pages 4
Place of publication USA
Publisher Lippincott Williams & Wilkins
Collection year 2000
Language eng
Subject C1
321299 Public Health and Health Services not elsewhere classified
730210 Environmental health
Abstract This paper describes the natural occurrence of the toxin, cylindrospermopsin, in two species of cyanobacteria found in Australia. The structure and chemical properties of this compound are described along with a nontoxic analog of cylindrospermopsin. The results of both intraperitoneal (IP) and oral dosing of mice show that hepatotoxicity is the main effect of cylindrospermopsin in vivo, but that a thrombo-hemorrhagic phenomenon is observed in a proportion of dosed animals. It has been shown that the toxin can be metabolized in vivo and that a bound metabolite occurs in the liver. Cytotoxicity experiments using cell cultures show that cylindrospermopsin is more cytotoxic to isolated rat liver hepatocytes than to other cell types. Risk assessment calculations show that guideline values for cylindrospermopsin in drinking water should lie in the low microgram per liter range.
Keyword Medical Laboratory Technology
Pharmacology & Pharmacy
Toxicology
Cylindrospermopsin
Cylindrospermopsis
Hepatotoxicity
Health
Umezakia Natans
Raciborskii
Q-Index Code C1

Document type: Journal Article
Sub-type: Article
Collection: National Research Centre for Environmental Toxicology Publications
 
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Created: Tue, 10 Jun 2008, 12:11:30 EST