Specific uptake of 5-hydroxytryptamine is reduced in lungs from hypoxic pulmonary hypertensive rats

Jeffery, Trina K., Bryan-Lluka, Lesley J. and Wanstall, Janet C. (2000) Specific uptake of 5-hydroxytryptamine is reduced in lungs from hypoxic pulmonary hypertensive rats. European Journal of Pharmacology, 396 2-3: 137-140. doi:10.1016/S0014-2999(00)00252-1


Author Jeffery, Trina K.
Bryan-Lluka, Lesley J.
Wanstall, Janet C.
Title Specific uptake of 5-hydroxytryptamine is reduced in lungs from hypoxic pulmonary hypertensive rats
Journal name European Journal of Pharmacology   Check publisher's open access policy
ISSN 0014-2999
1879-0712
Publication date 2000-05-19
Sub-type Article (original research)
DOI 10.1016/S0014-2999(00)00252-1
Volume 396
Issue 2-3
Start page 137
End page 140
Total pages 4
Editor W. H. Gispen
J. Bruinvels
F. P. Nijkamp
D. H. G. Versteeg
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2000
Language eng
Subject C1
320502 Basic Pharmacology
730106 Cardiovascular system and diseases
Abstract In this study, the aim was to determine whether 5-hydroxytryptamine (5-HT) removal by the pulmonary endothelium is reduced in 1-week hypoxic, pulmonary hypertensive rats by directly measuring [H-3]5-HT uptake in isolated lungs. In lungs from hypoxic rats, specific 5-HT uptake was reduced. This was due to a 50% decrease in the maximal initial rate of uptake rather than a decrease in affinity of 5-HT for its transporter. It is possible that reduced removal of 5-HT may contribute to the elevation in plasma levels of this vasoactive amine in pulmonary hypertension. (C) 2000 Elsevier Science B.V. Al rights reserved.
Formatted abstract
In this study, the aim was to determine whether 5-hydroxytryptamine (5-HT) removal by the pulmonary endothelium is reduced in 1-week hypoxic, pulmonary hypertensive rats by directly measuring [3H]5-HT uptake in isolated lungs. In lungs from hypoxic rats, specific 5-HT uptake was reduced. This was due to a 50% decrease in the maximal initial rate of uptake rather than a decrease in affinity of 5-HT for its transporter. It is possible that reduced removal of 5-HT may contribute to the elevation in plasma levels of this vasoactive amine in pulmonary hypertension.
Copyright © 2000 Elsevier Science B.V.
Keyword Pharmacology & Pharmacy
Chronic Hypoxia
5-ht (5-hydroxytryptamine, Serotonin) Uptake
Pulmonary Hypertension
Lung, Rat
Endothelial-cells
Serotonin Uptake
Artery
Q-Index Code C1
Additional Notes Published under "Short communication".

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Tue, 10 Jun 2008, 11:29:41 EST