Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib

Mashiba, Tasuku, Hirano, Toru, Turner, Charles H., Forwood, Mark R., Johnston, C. Conrad and Burr, David B. (2000) Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib. Journal of Bone and Mineral Research, 15 4: 613-620. doi:10.1359/jbmr.2000.15.4.613


Author Mashiba, Tasuku
Hirano, Toru
Turner, Charles H.
Forwood, Mark R.
Johnston, C. Conrad
Burr, David B.
Title Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib
Journal name Journal of Bone and Mineral Research   Check publisher's open access policy
ISSN 0884-0431
1523-4681
Publication date 2000-04
Sub-type Article (original research)
DOI 10.1359/jbmr.2000.15.4.613
Volume 15
Issue 4
Start page 613
End page 620
Total pages 8
Place of publication Washington, DC, U.S.A.
Publisher American Society for Bone and Mineral Research
Collection year 2000
Language eng
Subject C1
321017 Orthopaedics
730114 Skeletal system and disorders (incl. arthritis)
Formatted abstract
It has been hypothesized that suppression of bone remodeling allows microdamage to accumulate, leading to increased bone fragility. This study evaluated the effects of reduced bone turnover produced by bisphosphonates on microdamage accumulation and biomechanical properties of cortical bone in the dog rib. Thirty-six female beagles, 1-2 years old, were divided into three groups. The control group (CNT) was treated daily for 12 months with saline vehicle. The remaining two groups were treated daily with risedronate (RIS) at a dose of 0.5 mg/kg per day or alendronate (ALN) at 1.0 mg/kg per day orally. After sacrifice, the right ninth rib was assigned to cortical histomorphometry or microdamage analysis. The left ninth rib was tested to failure in three-point bending. Total cross-sectional bone area was significantly increased in both RIS and ALN compared with CNT, whereas cortical area did not differ significantly among groups. One-year treatment with RIS or ALN significantly suppressed intracortical remodeling (RIS, 53%; ALN, 68%) without impairment of mineralization and significantly increased microdamage accumulation in both RIS (155%) and ALN (322%) compared with CNT, Although bone strength and stiffness were not significantly affected by the treatments, bone toughness declined significantly in ALN (20%), Regression analysis showed a significant nonlinear relationship between suppressed intracortical bone remodeling and microdamage accumulation as well as a significant linear relationship between microdamage accumulation and reduced toughness. This study showed that suppression of bone turnover by high doses of bisphosphonates is associated with microdamage accumulation and reduced some mechanical properties of bone.
© 2000 American Society for Bone and Mineral Research
Keyword Endocrinology & Metabolism
Microdamage
Bone Remodeling
Bisphosphonate
Biomechanics
Histomorphometry
Aminobisphosphonate Alendronate
Mineral Density
Femoral-neck
Osteoporosis
Fractures
Term
Etidronate
Women
Intermittent
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
 
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Created: Tue, 10 Jun 2008, 11:15:49 EST