Visual responses of neurons in the middle temporal area of new World Monkeys after lesions of striate cortex

Rosa, Marcello G. P., Tweedale, Rowan and Elston, Guy N. (2000) Visual responses of neurons in the middle temporal area of new World Monkeys after lesions of striate cortex. The Journal of Neuroscience, 20 14: 5552-5563.

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Author Rosa, Marcello G. P.
Tweedale, Rowan
Elston, Guy N.
Title Visual responses of neurons in the middle temporal area of new World Monkeys after lesions of striate cortex
Journal name The Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
1529-2401
Publication date 2000-07-01
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 20
Issue 14
Start page 5552
End page 5563
Total pages 12
Editor G. M. Shepherd
Place of publication US
Publisher Society for Neuroscience
Collection year 2000
Language eng
Subject C1
320705 Sensory Systems
730111 Hearing, vision, speech and their disorders
Abstract In primates, lesions of striate cortex (V1) result in scotomas in which only rudimentary visual abilities remain. These aspects of vision that survive V1 lesions have been attributed to direct thalamic pathways to extrastriate areas, including the middle temporal area (MT). However, studies in New World monkeys and humans have questioned this interpretation, suggesting that remnants of V1 are responsible for both the activation of MT and residual vision. We studied the visual responses of neurons in area MT in New World marmoset monkeys in the weeks after lesions of V1. The extent of the scotoma in each case was estimated by mapping the receptive fields of cells located near the lesion border and by histological reconstruction. Two response types were observed among the cells located in the part of MT that corresponds, in visuotopic coordinates, to the lesioned part of V1. Many neurons (62%) had receptive fields that were displaced relative to their expected location, so that they represented the visual field immediately surrounding the scotoma. This may be a consequence of a process analogous to the reorganization of the V1 map after retinal lesions. However, another 20% of the cells had receptive fields centered inside the scotoma. Most of these neurons were strongly direction-selective, similar to normal MT cells. These results show that MT cells differ in their responses to lesioning of V1 and that only a subpopulation of MT neurons can be reasonably linked to residual vision and blindsight.
Keyword Neurosciences
Marmoset
Vision
Extrastriate
Receptive Fields
Blindsight
Scotoma
Callithrix-jacchus
Visuotopic Organization
Marmoset Monkey
Macaque Monkey
Reversible Inactivation
Topographic Plasticity
Retinal Lesions
Adult Cat
Mt
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Tue, 10 Jun 2008, 21:02:53 EST