Cerebrospinal fluid penetration of high doses of intravenous ciprofloxacin in meningitis

Lipman, J, Allworth, A and Wallis, SC (2000) Cerebrospinal fluid penetration of high doses of intravenous ciprofloxacin in meningitis. Clinical Infectious Diseases, 31 5: 1131-1133. doi:10.1086/317462


Author Lipman, J
Allworth, A
Wallis, SC
Title Cerebrospinal fluid penetration of high doses of intravenous ciprofloxacin in meningitis
Journal name Clinical Infectious Diseases   Check publisher's open access policy
ISSN 1058-4838
Publication date 2000-11
Sub-type Article (original research)
DOI 10.1086/317462
Volume 31
Issue 5
Start page 1131
End page 1133
Total pages 3
Place of publication Chicago
Publisher University of Chicago Press
Collection year 2000
Language eng
Subject C1
321010 Infectious Diseases
730101 Infectious diseases
0301 Analytical Chemistry
110310 Intensive Care
Abstract Nosocomial meningitis due to gram-negative organisms is a difficult clinical problem to manage because of both antibiotic resistance and poor penetration of many antimicrobials across the blood-brain barrier. Ciprofloxacin has potential in treating this condition when used in high doses. We investigated the plasma and cerebrospinal fluid (CSF) levels of ciprofloxacin in a patient with Pseudomonas aeruginosa meningitis who was treated with 400 mg of intravenous ciprofloxacin every 8 hours. Ciprofloxacin levels in plasma peaked at 10.29 mg/L without resulting in accumulation (8-hour trough levels, <1 mg/L), whereas the CSF level increased to 0.9 mg/L. This CSF level was confirmed to be similar 1 week later. After 1 week of therapy, during which there were no side effects attributable to ciprofloxacin, the organism was eradicated, and there was some clinical improvement. We recommend that 400 mg of intravenous ciprofloxacin every 8 hours be considered for treatment of difficult-to-treat gram-negative bacillary meningitis.
Keyword Immunology
Infectious Diseases
Microbiology
Pseudomonas-aeruginosa Meningitis
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 10 Jun 2008, 10:42:15 EST