Changes in the periodontal status of patients undergoing bone marrow transplantation

Pattni, R, Walsh, LJ, Marshall, RI, Cullinan, MP, Seymour, GJ and Bartold, PM (2000) Changes in the periodontal status of patients undergoing bone marrow transplantation. Journal of Periodontology, 71 3: 394-401. doi:10.1902/jop.2000.71.3.394

Author Pattni, R
Walsh, LJ
Marshall, RI
Cullinan, MP
Seymour, GJ
Bartold, PM
Title Changes in the periodontal status of patients undergoing bone marrow transplantation
Journal name Journal of Periodontology   Check publisher's open access policy
ISSN 0022-3492
Publication date 2000
Sub-type Article (original research)
DOI 10.1902/jop.2000.71.3.394
Volume 71
Issue 3
Start page 394
End page 401
Total pages 8
Place of publication Chicago
Publisher The American Academy of Periodontology
Collection year 2000
Language eng
Subject C1
320899 Dentistry not elsewhere classified
730112 Oro-dental and disorders
Abstract Background: Patients receiving an HLA-matched bone marrow transplant (BMT) from a relative or unrelated donor undergo a permanent alteration of their immune system, followed by a prolonged period of immunodeficiency. This study aimed to examine alterations in the periodontal status of patients over 6 months post-bone marrow transplantation. Methods: Thirty-seven patients scheduled for bone marrow transplantation participated in this study. One calibrated examiner carried out periodontal examinations (clinical and radiographic) immediately prior to and at 3 and 6 months after transplantation. All patients followed an intense oral care program. Subgingival plaque samples were analyzed by enzyme-linked immunosorbent assay (ELISA) for the presence of Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, and Prevotella intermedia. Data were subjected to statistical analyses to determine the relationships between the frequency distribution of the radiographic and clinical variables over time. Results: Gains in clinical attachment level (CAL) of ≤2 mm at 4 or more sites from baseline to 6 months post-BMT were noted in 9/16 patients (56%), while 6/16 (38%) patients experienced a loss of CAL ≤2 mm at 4 or more sites in the same period. At a site level, 4.8% of sites exhibited a gain in CAL ≤2 mm between baseline and 3 months post-BMT while 2.3% of sites showed a loss of CAL ≤2 mm in the same period. From baseline to 6 months, a gain in CAL of ≤2 mm was recorded at 3.1% of sites, and 2.4% of sites experienced a loss of ≤ mm. A significant improvement in the gingival index occurred between all sequential time periods when assessed at a site level. At a patient level, 11/18 (61%) patients showed a significant change in gingival index between baseline and 3 months and 10/16 (63%) between baseline and 6 months. There was no significant relationship between clinical changes and the prevalence of the periodontal pathogens at the various time periods. Conclusions: An improvement in periodontal health was recorded between baseline and 6 months post-transplantation. Most of the improvement in periodontal status was noted in the first 3 months after BMT, with a slight decline in periodontal health between 3 and 6 months post-transplant. No significant alteration was noted in the prevalence of periodontal pathogens during the study period. J Periodontol 2000;71:394-402.
Keyword Bone marrow transplantation
periodontal attachment
periodontal diseases/diagnosis
periodontal diseases/pathogenesis
dental plaque/microbiology
immune system
periodontal pathogens
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 10 Jun 2008, 10:24:06 EST