Chronic kidney disease patients have lower birth weight than the general Australian population

Al Salmi, I. S., Hoy, W. E., Wang, Z. Q., Healy, H., Gobe, G. C. and Shaw, J. (2006). Chronic kidney disease patients have lower birth weight than the general Australian population. In: Nephrology. Program and Abstracts from the 42nd Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology. 42nd Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN 2006), Melbourne, Australia, (A9-A9). 14-18 August 2006. doi:10.1111/j.1440-1797.2006.00656.x


Author Al Salmi, I. S.
Hoy, W. E.
Wang, Z. Q.
Healy, H.
Gobe, G. C.
Shaw, J.
Title of paper Chronic kidney disease patients have lower birth weight than the general Australian population
Conference name 42nd Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN 2006)
Conference location Melbourne, Australia
Conference dates 14-18 August 2006
Proceedings title Nephrology. Program and Abstracts from the 42nd Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology   Check publisher's open access policy
Journal name Nephrology   Check publisher's open access policy
Place of Publication Carlton, Australia
Publisher Blackwell Publishing
Publication Year 2006
Sub-type Published abstract
DOI 10.1111/j.1440-1797.2006.00656.x
ISSN 1320-5358
1440-1797
Volume 11
Issue Supp. 2
Start page A9
End page A9
Total pages 1
Language eng
Formatted Abstract/Summary
Background: To evaluate the relationship between birthweight and chronic kidney disease (CKD), including end stage kidney disease (ESKD).

Methods: Patients attending the Renal Department at the RBWH were asked about their birthweight (BW). Controls, matched for gender and within one year of age, were selected from participants from Victoria in the AusDiab study, to the second round of which questions about birthweight by self-report had been added.
Glomerular filtration rate (GFR) was measured using the modified MDRD formula.

Results: There were 139 matches. Of the 139 CKD patients, 71 were male, with age 54 (SD 11) years, and their mean (SD) GFR was 33.7 (SD25.6) ml/min.
Seventy three (37 males) were on renal replacement therapy. The table shows a striking difference in birthweight between the CKD and control group. This applied to both females and males (shown), and to people <50 and >50 yr old,
p = 0.007 and p < 0.001 respectively.

Conclusion: CKD in the general population in urban Queensland is significantly segregated among people with lower birthweights. This is the first such demonstration in Australia, and supports, but is more dramatic than, the findings by Lackland et al in the southeastern USA. It is compatible with the strong correlation of birthweight with nephron number and the hypothesis that lower nephron endowment enhances susceptibility to renal disease.
Subjects EX
321012 Nephrology and Urology
730115 Urogenital system and disorders
Keyword Chronic Kidney Disease (CKD)
End stage kidney disease (ESKD)
Queensland
Lower birthweight
Renal disease
Renal studies
Q-Index Code EX
Additional Notes Abstract # 1522

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Thu, 22 May 2008, 21:53:07 EST by Brenda Mason on behalf of Medicine - Royal Brisbane and Women's Hospital