Steady-state dendritic cells expressing cognate antgen terminate memory CD8+ T-cell responses

Kenna, Tony J., Thomas, Ranjeny and Steptoe, Raymond J. (2008) Steady-state dendritic cells expressing cognate antgen terminate memory CD8+ T-cell responses. Blood, 111 4: 2091-2100. doi:10.1182/blood-2007-07-103200


Author Kenna, Tony J.
Thomas, Ranjeny
Steptoe, Raymond J.
Title Steady-state dendritic cells expressing cognate antgen terminate memory CD8+ T-cell responses
Journal name Blood   Check publisher's open access policy
ISSN 0006-4971
1528-0020
Publication date 2008-02-15
Sub-type Article (original research)
DOI 10.1182/blood-2007-07-103200
Volume 111
Issue 4
Start page 2091
End page 2100
Total pages 10
Editor S. J. Shattil
Place of publication Washington, DC, United States
Publisher American Society of Hematology
Collection year 2008
Language eng
Subject 11 Medical and Health Sciences
Abstract Antigen stimulation of naive T cells in conjunction with strong costimulatory signals elicits the generation of effector and memory populations. Such terminal differentiation transforms naive T cells capable of differentiating along several terminal pathways in response to pertinent environmental cues into cells that have lost developmental plasticity and exhibit heightened responsiveness. Because these cells exhibit little or no need for the strong costimulatory signals required for full activation of naive T cells, it is generally considered memory and effector T cells are released from the capacity to be inactivated. Here, we show that steady-state dendritic cells constitutively presenting an endogenously expressed antigen inactivate fully differentiated memory and effector CD8+ T cells in vivo through deletion and inactivation. These findings indicate that fully differentiated effector and memory T cells exhibit a previously unappreciated level of plasticity and provide insight into how memory and effector T-cell populations may be regulated.
Keyword T cells
blood
Antigen
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Prepublished online as a Blood first edition paper on November 14 2007

 
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Created: Fri, 16 May 2008, 00:23:46 EST by Kylie Hengst on behalf of UQ Diamantina Institute