Using the maternal-fetal genotype incompatibility test to assess non-inherited maternal DRB1 coding alleles as rheumatoid arthritis risk factors

Hseih, Hsin-Ju, Palmer, Christina G. S., Harney, Sinead, Chen, Hsiu-Wen, Bauman, Lara, Brown, Matthew A. and Sinsheimer, Janet S. (2007) Using the maternal-fetal genotype incompatibility test to assess non-inherited maternal DRB1 coding alleles as rheumatoid arthritis risk factors. BMC Proceedings, 1 Supp. 1: S124.1-S124.4.

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UQ138369_OA.pdf Full text (Open Access) application/pdf 238.38KB 32
Author Hseih, Hsin-Ju
Palmer, Christina G. S.
Harney, Sinead
Chen, Hsiu-Wen
Bauman, Lara
Brown, Matthew A.
Sinsheimer, Janet S.
Title Using the maternal-fetal genotype incompatibility test to assess non-inherited maternal DRB1 coding alleles as rheumatoid arthritis risk factors
Journal name BMC Proceedings   Check publisher's open access policy
ISSN 1753-6561
Publication date 2007-12-18
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 1
Issue Supp. 1
Start page S124.1
End page S124.4
Total pages 4
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2008
Language eng
Subject C1
270206 Genetic Immunology
780105 Biological sciences
Abstract Non-inherited maternal antigens encoded by specific HLA-DRB1 alleles (NIMA) have been implicated as a rheumatoid arthritis (RA) risk factor. Using genotype data from North American Rheumatoid Arthritis Consortium study participants and the maternal-fetal genotype incompatibility (MFG) test, we find evidence for offspring allelic effects but no evidence for NIMA as a RA risk factor. We discuss possible reasons why our result conflicts with several previous studies (including one of our own) that used RA patients from northern Europe.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Wed, 14 May 2008, 11:04:05 EST by Kylie Hengst on behalf of UQ Diamantina Institute