Healthy aging: Regulation of the metabolome by cellular redox modulation and prooxidant signaling systems:the essential roles of superoxide anion and hydrogen peroxide

Linnane, Anthony William, Kios, Michael and Vitetta, Luis (2007) Healthy aging: Regulation of the metabolome by cellular redox modulation and prooxidant signaling systems:the essential roles of superoxide anion and hydrogen peroxide. Biogerontology, 8 5: 445-467. doi:10.1007/s10522-007-9096-4


Author Linnane, Anthony William
Kios, Michael
Vitetta, Luis
Title Healthy aging: Regulation of the metabolome by cellular redox modulation and prooxidant signaling systems:the essential roles of superoxide anion and hydrogen peroxide
Journal name Biogerontology   Check publisher's open access policy
ISSN 1389-5729
1573-6768
Publication date 2007-10
Sub-type Article (original research)
DOI 10.1007/s10522-007-9096-4
Volume 8
Issue 5
Start page 445
End page 467
Total pages 23
Place of publication Amsterdam, Netherlands
Publisher Elsevier Science
Collection year 2008
Language eng
Subject 270102 Cell Metabolism
320307 Medical Biochemistry - Other
C4
730203 Health related to ageing
1101 Medical Biochemistry and Metabolomics
Abstract The production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) has long been proposed as leading to random deleterious modification of macromolecules with an associated progressive development of age associated systemic disease. ROS and RNS formation has been posited as a major contributor to the aging process. On the contrary, this review presents evidence that superoxide anion (and hydrogen peroxide) and nitric oxide (and peroxynitrite) constitute regulated prooxidant second messenger systems, with specific sub-cellular locales of production and are essential for normal metabolome and physiological function. The role of these second messengers in the regulation of the metabolome is discussed in terms of radical formation as an essential contributor to the physiologically normal regulation of sub-cellular bioenergy systems; proteolysis regulation; transcription activation; enzyme activation; mitochondrial DNA changes; redox regulation of metabolism and cell differentiation; the concept that orally administered small molecule antioxidant therapy is a chimera. The formation of superoxide anion/hydrogen peroxide and nitric oxide do not conditionally lead to random macromolecular damage; under normal physiological conditions their production is actually regulated consistent with their second messenger roles. Copyright Springer Science+Business Media B.V. 2007
Keyword Metabolome regulation
Superoxide anion
Hydrogen peroxide
Nitric oxide
Peroxynitrite
Second messengers
Proton motive force
Cellular bioenergy
Proteolysis
Cellular organellar function
Prooxidants
Antioxidants
Mitochondrial DNA
Redox poise modulation
Q-Index Code C4

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
 
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Created: Fri, 09 May 2008, 09:24:31 EST by Maree Knight on behalf of School of Medicine