ASSESSING TOXIC POTENCY OF AMBIENT AIR USING BIO-ANALYTICAL METHODS: A CASE STUDY USING PASSIVE AIR SAMPLING

Kennedy, K., Tang, J. M., Bartkow, M. E., Hawker, D., Macova, M., Thier, R. and Mueller, J. F. (2007). ASSESSING TOXIC POTENCY OF AMBIENT AIR USING BIO-ANALYTICAL METHODS: A CASE STUDY USING PASSIVE AIR SAMPLING. In: , Clean Air Partnerships: Coming Together for the Future. 14th International Union of Air Pollution Prevention and Environmental Protection Associations (IUAPPA) World Congress 2007, incorporating 18th Clean Air Society of Australia and New Zealand (CASANZ) Conference, Brisbane Convention and Exhibition Centre, Brisbane, Queensland, Australia, (1-6). 9 - 13 September 2007.

Author Kennedy, K.
Tang, J. M.
Bartkow, M. E.
Hawker, D.
Macova, M.
Thier, R.
Mueller, J. F.
Title of paper ASSESSING TOXIC POTENCY OF AMBIENT AIR USING BIO-ANALYTICAL METHODS: A CASE STUDY USING PASSIVE AIR SAMPLING
Conference Paper Type Fully Published Paper
Conference name 14th International Union of Air Pollution Prevention and Environmental Protection Associations (IUAPPA) World Congress 2007, incorporating 18th Clean Air Society of Australia and New Zealand (CASANZ) Conference
Conference location Brisbane Convention and Exhibition Centre, Brisbane, Queensland, Australia
Conference dates 9 - 13 September 2007
Proceedings title Clean Air Partnerships: Coming Together for the Future
Place published Eastwood, NSW, Australia
Publisher Clean Air Society of Australia and New Zealand
Publication date 2007
Year available 2007
ISBN 978-0-9757571-6-1
Start page 1
End page 6
Total pages 6
Collection year 2008
Language eng
Abstract/Summary Hazardous air pollutants are present in ambient air as components of complex mixtures a large proportion of which remains uncharacterised in terms of exposure or effect. Current regulatory approaches however focus on relatively few individual components of this mixture, which are sufficiently characterised, for monitoring and potential regulation. Bio-analytical assessments may be undertaken for complex mixtures for specific mechanisms of toxicity. These assessments would provide a screening tool for overall toxic potency. A framework is outlined for the application of a mode of action test battery for these assessments. Passive air samplers which may be deployed over wide spatial scales simultaneously are particularly suited as a screening tool for assessing exposure. A preliminary field study was conducted at five sites in Queensland using semipermeable membrane devices, a type of passive air sampler. These samples were then assessed for overall toxic potency using the umuC assay (genotoxicity) and analysed for polycyclic aromatic hydrocarbons. Both toxicity units and maximum induction ratios were determined as overall potency estimates. The sum of benzo[a]pyrene equivalents (ΣBaP Eq) was determined for co-deployed samplers. Significant differences were found between some sites using overall potency estimates. A significant correlation was found between toxicity units and the ΣBaP Eq. However, this parameter does not appear to identify the most potent site as assessed bio-analytically suggesting that other non-quantified components may be responsible for observed effect in certain cases.
Subjects E1
259902 Environmental Chemistry (incl. Atmospheric Chemistry)
260699 Atmospheric Sciences not elsewhere classified
291104 Environmental Technologies
Keyword Passive air sampling
Bio-analytical assessment
In vitro Toxicity testing
Polycyclic aromatic hydrocarbons
Q-Index Code E1
Q-Index Status Confirmed Code

 
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Created: Thu, 08 May 2008, 10:34:28 EST by Marie-Louise Moore on behalf of National Res Centre For Environmental Toxicology