SOCS1: a host factor required for HIV-1 Gag trafficking

Sivakumaran, Haran and Harrich, David (2008) SOCS1: a host factor required for HIV-1 Gag trafficking. Future HIV Therapy, 2 3: 247-251. doi:10.2217/17469600.2.3.247

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Author Sivakumaran, Haran
Harrich, David
Title SOCS1: a host factor required for HIV-1 Gag trafficking
Journal name Future HIV Therapy   Check publisher's open access policy
ISSN 1746-9600
Publication date 2008-05
Sub-type Article (original research)
DOI 10.2217/17469600.2.3.247
Open Access Status File (Author Post-print)
Volume 2
Issue 3
Start page 247
End page 251
Total pages 5
Place of publication London, United Kingdom
Publisher Future Medicine
Language eng
Subject 270303 Virology
270105 Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
Formatted abstract
Evaluation of: Ryo A, Tsurutani N, Ohba K et al.: SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag. Proc. Natl Acad. Sci. USA 105, 294-299 (2008). Gag is an essential HIV protein that is responsible for assembling infectious viral particles. The journey of Gag from synthesis to virion formation is an attractive target for anti-HIV therapy. While a lot is known about the cellular factors required for virion assembly and budding, relatively little is known about factors required for Gag trafficking. Ryo and colleagues provide the first evidence of such a factor, the suppressor of cytokine signaling 1 (SOCS1). They demonstrated that SOCS1 is important for Gag stability and plays a critical role in its trafficking within the cell. Without SOCS1 Gag accumulates in perinuclear bodies and is degraded by lysosomes. The reviewed paper thus highlights a new and novel target for stopping the production of HIV, a target that belongs to the relatively invariant host rather than the rapidly evolving virus.
Keyword HIV
Gag
SOCS1
trafficking
protein stability
host factors
immunotherapy
bevirimat
journal article review
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes This is an author version of an article published as Haran Sivakumaran & David Harrich, SOCS1: a host factor required for HIV-1 Gag trafficking, Future HIV Therapy, May 2008, Vol. 2, No. 3, Pages 247-251 (doi:10.2217/17469600.2.3.247). This is the post-print authors' manuscript of the article, not the publisher's final version. Copyright 2008 Future Medicine Ltd.

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Student Publications
 
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Created: Wed, 07 May 2008, 11:08:37 EST by Dhivakaren (Haran) Sivakumaran on behalf of Scholarly Communication and Digitisation Service