Simkania negevensis in bronchoalveolar lavage of lung transplant recipients: A possible association with acute rejection

Husain, Shahid, Kahane, Simona, Friedman, Maureen G., Paterson, David L., Studer, Sean, McCurry, Kenneth R., Wolf, Dana G., Zeevi, Adriana, Pilewski, Joseph and Greenberg, David (2007) Simkania negevensis in bronchoalveolar lavage of lung transplant recipients: A possible association with acute rejection. Transplantation, 83 2: 138-143. doi:10.1097/01.tp.0000250477.65139.02


Author Husain, Shahid
Kahane, Simona
Friedman, Maureen G.
Paterson, David L.
Studer, Sean
McCurry, Kenneth R.
Wolf, Dana G.
Zeevi, Adriana
Pilewski, Joseph
Greenberg, David
Title Simkania negevensis in bronchoalveolar lavage of lung transplant recipients: A possible association with acute rejection
Formatted title
Simkania negevensis in bronchoalveolar lavage of lung transplant recipients: A possible association with acute rejection
Journal name Transplantation   Check publisher's open access policy
ISSN 0041-1337
Publication date 2007
Sub-type Article (original research)
DOI 10.1097/01.tp.0000250477.65139.02
Volume 83
Issue 2
Start page 138
End page 143
Total pages 6
Editor D. H. Sachs
J. A. Bradley
J. Neuberger
K. J. Wood
M. Suthanthiran
M. A. Hardy
Place of publication Baltimore, U.S.A.
Publisher Lippincott Williams & Wilkins
Collection year 2008
Language eng
Subject 321010 Infectious Diseases
730101 Infectious diseases
CX
Abstract Background. Simkania negevensis is a novel organism closely related to chlamydiae. The organism has been associated with community acquired pneumonia and acute exacerbation of chronic obstructive pulmonary disease. The prevalence and pathogenic potential of S. negevensis is not known in lung transplant recipients. Methods. In this multicenter study comparative analysis of bronchoalveolar lavage (BAL) in lung transplants (Tx) and kidney Tx, immunocompromised and nasopharyngeal (NP) washes of immunocompetent patients was done. The BAL specimens were tested by nested polymerase chain reaction (PCR) for C. pneumoniae and S. negevensis. Selected S. negevensis positive PCR cases were confirmed by culture. Results. In the initial 41 BAL samples S. negevensis was detected in 97.5% (40/41) of lung transplant recipients as compared to 14.1% (1/7) in other organ transplant recipients (P<0.0001). In the sequential samples of 19 lung transplant recipients, 59% (24/41) had concomitant positive PCR and rejection as compared to 30% (3/10) who had negative PCR but had rejection (P=0.16). S. negevensis infection had hazard ratio of 3.29 (95% CI: 0.73-14.76; P=0.11) for developing acute rejection. Conclusion. S. negevensis is highly prevalent in liver Tx recipients and may be associated with acute rejection. (C) 2007 Lippincott Williams & Wilkins, Inc.
Q-Index Code CX
Additional Notes CX at schools request - no UQ byline

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Tue, 06 May 2008, 09:26:39 EST by Brenda Mason on behalf of Medicine - Royal Brisbane and Women's Hospital