Porphyrins as the early biomarkers for arsenic exposure of human

Deng, G. D., Zheng, B. S., Zhai, C., Wang, J. P. and Ng, J. C. (2007) Porphyrins as the early biomarkers for arsenic exposure of human. Huan jing ke xue= Huanjing kexue, 28 5: 1147-1152.


Author Deng, G. D.
Zheng, B. S.
Zhai, C.
Wang, J. P.
Ng, J. C.
Title Porphyrins as the early biomarkers for arsenic exposure of human
Journal name Huan jing ke xue= Huanjing kexue   Check publisher's open access policy
ISSN 0250-3301
Publication date 2007-05
Year available 2007
Sub-type Article (original research)
Volume 28
Issue 5
Start page 1147
End page 1152
Total pages 6
Place of publication China
Publisher Ke xue zhu ban she
Collection year 2008
Language chi
Subject C1
300503 Epidemiology
320504 Toxicology (incl. Clinical Toxicology)
321201 Environmental and Occupational Health and Safety
Abstract To investigate the effects of arsenic exposure on porphyrins excretion profiles in human, porphyrins were measured by HPLC and total arsenic by HG-AAS in urine samples collected from arsenicosis-endemic areas and control sites in Guizhou Province. Analytical data showed that urinary uroporphyrin-III and coproporphyrin-III were significantly elevated in arsenic-exposed group compared with those in control group, while urinary coproporphyrin-I was not significantly higher in arsenic-exposed group than that in control group. Not any significant difference was found in porphyrins between the male and female except for 20-40 years age group. As far as age was concerned, arsenic-exposed group of <20 years showed significant increases in uroporphyrin-III and coproporphyrin-III compared with the control group of <20 years. Similarly, arsenic-exposed groups of 20-40 years and >40 years also showed significant increases in coproporphyrin-III compared with corresponding age groups of control. Besides, there were positive correlations between the urinary arsenic and total coproporphyrin, and total porphyrin. The effects of arsenic exposure were associated with increased porphyrins excretion, which was suggested that porphyrins were possible to be used as biomarkers of early health effect due to arsenicosis.
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Fri, 02 May 2008, 11:58:25 EST by Marie-Louise Moore on behalf of National Res Centre For Environmental Toxicology