A pneumococcal MerR-like regulator and S-nitrosoglutathione reductase are required for systemic virulence

Stroeher, Uwe H., Kidd, Stephen P., Stafford, Sian L., Jennings, Michael P., Paton, James C. and McEwan, Alastair G. (2007) A pneumococcal MerR-like regulator and S-nitrosoglutathione reductase are required for systemic virulence. The Journal of Infectious Diseases, 196 12: 1820-1826.


Author Stroeher, Uwe H.
Kidd, Stephen P.
Stafford, Sian L.
Jennings, Michael P.
Paton, James C.
McEwan, Alastair G.
Title A pneumococcal MerR-like regulator and S-nitrosoglutathione reductase are required for systemic virulence
Journal name The Journal of Infectious Diseases  (ERA 2012 Listed)    (ERA 2010 Rank A)   Check publisher's open access policy
Publication date 2007-12-15
Sub-type Article
DOI 10.1086/523107
Volume number 196
Issue number 12
ISSN 0022-1899
Start page 1820
End page 1826
Total pages 7
Place of publication Chicago, IL, USA
Publisher University of Chicago Press
Collection year 2008
Language eng
Subject 320401 Medical Bacteriology
C1
730101 Infectious diseases
Abstract A transcriptional regulator, NmlRsp, has been identified in Streptococcus pneumoniae that is required for defense against nitric oxide (NO) stress. The nmlRsp gene is cotranscribed with adhC, which encodes an alcohol dehydrogenase that is able to reduce S-nitrosoglutathione (GSNO) with NADH as reductant. nmlRsp and adhC mutants exhibited a reduced level of NADH-GSNO oxidoreductase activity and were more susceptible to killing by NO than were wild-type cells. Comparison of the virulence of wild-type and mutant strains by use of a mouse model system showed that NmlRsp and AdhC do not play a key role in the adherence of pneumococci to the nasopharynx in vivo. An intraperitoneal challenge experiment revealed that both NmlRsp and AdhC were required for survival in blood. These data identify novel components of a NO defense system in pneumococci that are required for systemic infection.
Keyword Streptococcus-pneumoniae
Nitric-oxide
Family
model
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes Electronically published 15 November 2007.

 
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