Monitoring of cadmium toxicity in a Thai population with high-level environmental exposure

Teeyakasem, W., Nishijo, M., Honda, R., Satarug, S., Swaddiwudhipong, W. and Ruangyuttikarn, W. (2007) Monitoring of cadmium toxicity in a Thai population with high-level environmental exposure. Toxicology Letters, 169 3: 185-195. doi:10.1016/j.toxlet.2007.01.004

Author Teeyakasem, W.
Nishijo, M.
Honda, R.
Satarug, S.
Swaddiwudhipong, W.
Ruangyuttikarn, W.
Title Monitoring of cadmium toxicity in a Thai population with high-level environmental exposure
Journal name Toxicology Letters   Check publisher's open access policy
ISSN 0378-4274
Publication date 2007-03
Year available 2007
Sub-type Article (original research)
DOI 10.1016/j.toxlet.2007.01.004
Volume 169
Issue 3
Start page 185
End page 195
Total pages 11
Editor J.P. Kehrer
W. Dekant
Place of publication New York, United States
Publisher Amsterdam : Elsevier/North-Holland
Collection year 2008
Language eng
Subject C1
321201 Environmental and Occupational Health and Safety
730207 Health related to specific ethnic groups
Abstract This study evaluated the utility of single and combined measurements of cadmium toxicity markers for surveillance purposes, using a sample of 224 individuals, 30–87 years of age, who were residents of cadmium polluted area in Mae Sot District, Tak Province, Thailand. Urinary cadmium levels excreted by them ranged between 1 and 58 μg/g creatinine with geometric mean of 8.2 μg/g creatinine which was 16-fold greater than the average for the general Thai population of 0.5 μg/g creatinine. The urinary markers evaluated were total protein, albumin, N-acetyl-β-d-glucosaminidase (NAG), lysozyme, β2-microglobulin (β2-MG) and 1-microblobulin (1-MG). Among these markers, only NAG showed a positive correlation with urinary cadmium in both male and female subjects with and without disease (r = 0.43–0.71). Further, the prevalence rates for urinary NAG above 8 units/g creatinine (NAG-uria) increased with exposure levels in a dose dependent manner (p = 0.05) among subjects with disease. In contrast, however, increased prevalence of β2-MG above 0.4 mg/g creatinine (β2-MG-uria) was associated with cadmium above 5 μg/g creatinine only in those without disease (POR = 10.6 and 7.8 for 6–10 and >10 μg/g creatinine). Prevalence rates for abnormal excretion of all other markers, except albumin, were markedly increased among those having β2-MG-uria with and without disease (χ2-test, p ≤ 0.001–0.02). Thus, urinary β2-MG and NAG should be used together with urinary cadmium in the monitoring of renal toxicity in a population exposed to high-level cadmium coupled with high prevalence of chronic diseases.
Keyword Cadmium
Environmental pollution
Renal impairment
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2008 Higher Education Research Data Collection
National Research Centre for Environmental Toxicology Publications
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Created: Thu, 01 May 2008, 13:07:43 EST by Marie-Louise Moore on behalf of National Res Centre For Environmental Toxicology